UNIVERSIDAD CENTRAL DEL ECUADOR

Efecto antioxidante del extracto hidroalcohólico de tilia platyphyllos scopoli “tilo de hoja ancha” en isquemia-reperfusión cerebral experimental en ratas

Luis Emilio Carranza Quispe, Orlando Enrique Pretel Sevillano

Resumen


Los accidentes cerebrovasculares con sus complicaciones neurológicas son una de las principales causas de morbilidad y mortalidad en el mundo. En la actualidad se busca alternativas para tratar o disminuir el daño haciendo uso de propiedades de plantas medicinales. El presente trabajo evaluó el efecto antioxidante del extracto hidroalcohólico de Tilia platyphyllos Scopoli “tilo de hoja ancha” en isquemia-reperfusión (I/R) cerebral experimental en ratas. Materiales y métodos: Se evaluó el efecto neuroprotector de DE50 (300 mg/kg) y DE100 (600 mg/kg) de la planta frente a la lesión producida por la I/R en el cerebro de ratas, mediante la evaluación de radicales libres y ceruloplasmina,. Las dosis de DE50 y DE100 mostraron su capacidad antioxidante contra la I/R. El mayor efecto neuroprotector ocurrió en la dosis más alta. Sugerimos que la planta T. platyphyllos Scopoli posee efecto antioxidante contra la lesión hipóxica tisular inducida producida por la I/R en ratas.


Palabras clave


accidentes cerebrovasculares; ceruloplasmina; isquemia-reperfusión; neuroprotector; radicales libres; tilia platyphyllos scopoli

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Referencias


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