Medicina y Genoma Humano
Resumen
La genética, la ciencia de la herencia, estudia las semejanzas y diferencias entre organismos relacionados que resultan de la interacción de sus genes y el
medio ambiente. La genómica se encarga del estudio de conjuntos completos de genes y sus interacciones, más que del estudio de genes o proteínas específicos.
La medicina genómica se basa en el conocimiento de los genes, sus productos y funciones, para ofrecer mejores respuestas a gran escala a los grandes retos de la salud, particularmente enfocada al diagnóstico temprano, monitoreo, prevención y tratamiento (cáncer, retardo mental, malformaciones congénitas, diabetes, reacciones adversas a medicamentos, entre otros).
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Citas
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2. Claverie JM (2001). What if there are only 30,000 human genes? Science 291(5507): 1255-1257.
3. Collins FS, McKusick VA (2001). Implications on the Human Genome Project for medical Science. JAMA 285(5):540-544.
4. Danzón P, Towse A (2000). The genomic revolution: is the real risk under-investment rather than bankrupt health care systems? J Health Serv Res Policy 5(4):253-254.
5. Fears R, Roberts D, Poste G (2000). Rational or rationed medicine? The promise of genetics to improve clinical practice. BMJ 320: 933-935.
6. Figuera LE, Barrera HA, Cantu JM. El Proyecto del Genoma Humano. (1996). Ciencia y Desarrollo 126: 32-37.
7. Jimenez-Sanchez G, Childs B, Valle D (2001). Human disease genes. Nature 409: 853-855.
8. Lander ES, Linton LM, Birre'n B et al (2001). Initial sequencing and analysis of the human genome. Nature (409) 860-921.
9. McKinnon WC, Baty BJ, Bennet RL, et al (1997). Predisposition genetic testing for late-onset disorders in adults: a position paper of the National Society of Genetic Counselors. JAMA 278: 1217-1220.
10. Mitchel LZ (1998). Primary care doctors seen for genetic disorders. Pediatric News 32(7): 46.
11. Peltonen L, McKusick VA (2001). Dissecting human disease in the postgenomic era. Science 291 (5507):1224-1229.
12. Science and Technology Indicators at a glance. (1998). SEP-CONACYT, México.
13. Tucker ME (2000). Genetic Medicine Predicted to Have A Big Impact on Pediatric Practice. Pediatric News 34(4): 44.
14. US Department of Health and Human Services and US Department of Energy. (1990). Understanding our genetic inheritance, the US Human Genome Project the first five years 1991-1995. NTIS, US Department of Commerce, Springfield, VA.
15. Venter JC, Adams MD, Myers MW et al (2001). The sequence of the human genome. Science Feb 16, 1304- 1351.
16. Wertz DC (1997). Society and the not-so-new genetics: What are we afraid of? Some future predictions from a social scientist. The Journal of contemporary héalth law and policy. The Catholic University of America. Vol.13.
17. Wolpert CM (2000). Human genomics in clinical practice: Bridging the gap. Clin Rev 10(7): 67-86.
18. World Health Organization (1998). Proposed international guidelines on ethical issues in Medical Genetics and Genetic services. Human Genetics program.
19. World Health Organization (1998). Statements of WHO experts advisory group on ethical issues in Medical Genetics.
2. Claverie JM (2001). What if there are only 30,000 human genes? Science 291(5507): 1255-1257.
3. Collins FS, McKusick VA (2001). Implications on the Human Genome Project for medical Science. JAMA 285(5):540-544.
4. Danzón P, Towse A (2000). The genomic revolution: is the real risk under-investment rather than bankrupt health care systems? J Health Serv Res Policy 5(4):253-254.
5. Fears R, Roberts D, Poste G (2000). Rational or rationed medicine? The promise of genetics to improve clinical practice. BMJ 320: 933-935.
6. Figuera LE, Barrera HA, Cantu JM. El Proyecto del Genoma Humano. (1996). Ciencia y Desarrollo 126: 32-37.
7. Jimenez-Sanchez G, Childs B, Valle D (2001). Human disease genes. Nature 409: 853-855.
8. Lander ES, Linton LM, Birre'n B et al (2001). Initial sequencing and analysis of the human genome. Nature (409) 860-921.
9. McKinnon WC, Baty BJ, Bennet RL, et al (1997). Predisposition genetic testing for late-onset disorders in adults: a position paper of the National Society of Genetic Counselors. JAMA 278: 1217-1220.
10. Mitchel LZ (1998). Primary care doctors seen for genetic disorders. Pediatric News 32(7): 46.
11. Peltonen L, McKusick VA (2001). Dissecting human disease in the postgenomic era. Science 291 (5507):1224-1229.
12. Science and Technology Indicators at a glance. (1998). SEP-CONACYT, México.
13. Tucker ME (2000). Genetic Medicine Predicted to Have A Big Impact on Pediatric Practice. Pediatric News 34(4): 44.
14. US Department of Health and Human Services and US Department of Energy. (1990). Understanding our genetic inheritance, the US Human Genome Project the first five years 1991-1995. NTIS, US Department of Commerce, Springfield, VA.
15. Venter JC, Adams MD, Myers MW et al (2001). The sequence of the human genome. Science Feb 16, 1304- 1351.
16. Wertz DC (1997). Society and the not-so-new genetics: What are we afraid of? Some future predictions from a social scientist. The Journal of contemporary héalth law and policy. The Catholic University of America. Vol.13.
17. Wolpert CM (2000). Human genomics in clinical practice: Bridging the gap. Clin Rev 10(7): 67-86.
18. World Health Organization (1998). Proposed international guidelines on ethical issues in Medical Genetics and Genetic services. Human Genetics program.
19. World Health Organization (1998). Statements of WHO experts advisory group on ethical issues in Medical Genetics.
Publicado
2017-06-09
Cómo citar
1.
García-Ortiz JE, Figuera LE, Cantú JM. Medicina y Genoma Humano. Rev Fac Cien Med (Quito) [Internet]. 9 de junio de 2017 [citado 8 de mayo de 2024];27(1):7-11. Disponible en: https://revistadigital.uce.edu.ec/index.php/CIENCIAS_MEDICAS/article/view/958
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ARTÍCULOS ORIGINALES
