Vitamina "A" y riesgos de teratogenicidad
Resumen
Se realiza una revisión bibliográfica acerca de los posibles efectos indeseables y/o teratogénicos en general y del tubo neural en particular, que la Vitamina "A" y sus derivados retinoides sintéticos podrían producir, tanto a nivel experimental en animales, como hallazgos yatrogénicos en humanos, cuando mujeres en edad reproductiva o durante la gestación, ingieren altas dosis de vitamina A, debido a una mala prescripción médica o por automedicación.
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1. National Research Council: "Recomended dietary allowances". lOth ed. Washington, DC. National Academy Press, 1989; 84.
2. Underwood BA: "The safe use of vitamin A by women in the reproductive years. Report o f the International Vitamin A Consultative groUp. Ápril 1986. Washington the Group, 1986.
3. Teratology Society: "Recommendations for Vitamin A use in pregnancy (position statement)". Teratol, 1987; 35: 269-275.
4. Pinnock C, Alderman Ch P: "The potential for teratogenicity of vitamin A and its congeners". The Medical Journal of Australia, 1992; 157: 804-809.
5. Laurence KM: "Prevention o f Neural Tube Defects by Improvement in maternal diet and Preconceptional Folie Acid Suppléméntatión". Prevention o f Physical and Mental Congenital Defects, Part B; Epydemiology, Early Detection and Therapy, and Environmental Factors, 1985; 383-388.
6. Laurence KM, Campbell H, James N: "The role o f improvement in maternal diet and Preconceptional Folie Acid .Supplementation in the Prevention of neural Defects. In Dobbing J, eds: "Prevention of Spina Bifida and other Neuronal Tube Defects" London: Academic Press, 1983; 85-106.
7. Godfrey PO, Erickson JD: "Vitamin A and Birth Defects. Continuing Caution is Needed." N. Engl J Med, 1995; 21(333): 1414-1415.
8. USA: Recommendations for the use of folie acid to reduce the riumber o f cases o f spina bifida and other neural tube defects. MMWRB Morb Mortal Wkly Rep, 1987; 36: 80-82.
9. USA: Department o f health and Human Semces, Public Health Service, Center for Disease Control. Recommendations for the use of folie acid to reduce the number o f cases o f spine bifida and other neural tube defects. MMWR, 1 9 92;41:1-7.
10. Pérez-Escamilla R: " Periconcéptional Folie Acid and Neural Tube Defects: Public Health Issues". Bulletin od PAHO, 1995;. 29(3): 250-259.
11. Rothman K, Moore L, Singer M, et al. "Teratogenicity of High Vitamin A Intake". N Engl J Med, 1995; 21(333): 1369-1373.
12. Xui-Dao D, Chen A, Reidy J, ét al: "Folie acid and chromosome breakage". MutationRes, 1986; 174: 115-119.
13. Wald NJ, Hackshaw AK, Stone R, Nefertriti A: "Blood folie acid a,nd vitamin B12 in relation to neural tube defects" Br J Obstet Gynaecol, 1996; 103: 319- 324.
14. Blot L, Rey A, Kaltwasser JP, et al: "Folate and Iron Deficiencies in Mothers andThéir Newbom Children". Matemo-fetal Relations in Iron and Foliate Deficiencies. Springer-Verlag, 1982; 297-303.
15. Gillberg Ch, Wahlstrom J, Johansson R, et al: "Folie Acid as an adjunct in the treatment o f children with the autism fragile-X syndroffie :(ApRAX)". Developmental Mediciñe árid Child Ñeurology, 1986; 28: 624-627.
16. Blot L, Papiemik E, Kaltwasser JP, Wemer E, Techemia G: "Influence of routine administration o f folie acid and iron during pregnancy". Gynecol Obstet Invest, 1981; 12: 294.
17. Baumslag N, EdelsteinT, Metz J: "Reduction of incidence o f prematurely by folie acid supplementation in pregnancy". Br Med J, Í970; 1: 16.
18. Wolbach SB, Howe PR: "Tissue changes Following deprivation o f fat soluble A vitamin". J Exp Med, 1925; 42: 753-777.
19. Chytil F: "The lungs and vitamin A". A. Am J Physiol, 1992; 262: 517-527.
20. Studer M, Poperl H, Marshall H, et al: " Role of a conserved retinoic acid response element in rhombomere restriction o f Hoxb-l'\ Science, 1994; 265: 728-1732.
21. Bigby M, Stem RS: "Adverse reactions to isotretionin". J Am Acad Dermatol, 1988; 18: 543-552.
22. Waíren EW, Kinandera U: "Use o f retinoids in the treatment o f psoriasis". Clin Pharm, 1989: 8: 344-351.
23. Lucek RW, Colbum WA: "Clinical pharmocokinetics o f the retinoids". Clin Pharmacokinétic, 1985; 10: 38-62.
24. Geeleñ JA: "Hypervitaminosis A induced teratogenesis. CRC; Crit Rev Toxicol, 1979; 6: 351-375.
25. Jarvis BL, Johnston MC, Sulick KK: "Congenital malformations of the external middle an inner earproduced by isotretionin exposure in mouse embryos". Otolaryngol Head Neck Surg, 1990; 102: 391-401.
26. Da Costa D, de Fária G, Dias J, Bariani R: Acao Teratogena de Hipervitaminose A, com especial enfase sobre o globo ocular erri fetos.de ratos". Revista Goiana de Medicina, 1991; 37: 15-22.
27. Brentegani L, Sala M, Lopes R: "Estudio morfométrico y estereólógico de las alteraciones provocadas por hipervitaminosis A eb la glándula submandibular del hámster". Rev Fac Farm Odont Rib Preto, 1987; 144-147.
28. ILADIBA: "Exceso de vitamina A se asocia con desarrollo de de defectos congénitos", 1995; 63.
29. Vogt HJ, Ewers R: "13-cis-retinoic acid and spermatogenesis investigations by spermatólogy and impulse cytophotometry". Hautartz, 1985; 36: 281-286.
30. Rosa FW: "Teratogenicity of Isotretionin". Lancet, 1983; 2; 513.
31. Lammer E, Chen D, Hoar R, et al: "Retinoic acid embryophaty". N Engl J Med, 1985; 313: 837-841.
32. Doering PL, Araujo OE, Frohnapple DJ, et al: "Pattems o f prescribing isotretionin: focus on women of childbeanng potential". Ann Pharmacother,1992; 26: 155-161.
33. Stem RS: "When a uniquely effective drug is teratogenic. The case o f isotretionin". N Engl J Med, 1989; 320: 1007-10Ó9.
34. Alarcón M, Jonckree M, Sánchez de Molina D, cois: "Modificaciones dél Metabolismo proteico en la hipervitaminosis A aguda, en ratas". Acta Cient, 1986; 37(2): 162-169.
35. Nelsoñ M: (editorial). "Vitamina A liver consumption and risk of birth defecls". BMJ, 1990; 301: 1176.
36. Camera G, Pegfiasco P: "Ear malformation in baby bomto mother using tretinoin cream (letter)". Lancet, 1982; 339: 687.
37. Lammer EJ: "Embryóphathy in an infant conserved oné year after termination of maternal etretinate". Lancet 1988; 2: 1080-1081.
38. Martiñez-Frias ML, Salvador J: "Epidemiological aspeets o f prenatal exposure to high doses of Vitamin A in Spain". Eur J Epidemiol, 1990; 6: 118-123.
39. Werler MM, Lammer EJ, Rosenberg, L, Mitchel AA: "Maternal vitamin A supplementation in relation to selected birth defects". Teratology, 1990; 42: 497-503.
40. Choo V: "High-dose retinol associated with birth defects". Lancet, 1995; 36: 1027.
2. Underwood BA: "The safe use of vitamin A by women in the reproductive years. Report o f the International Vitamin A Consultative groUp. Ápril 1986. Washington the Group, 1986.
3. Teratology Society: "Recommendations for Vitamin A use in pregnancy (position statement)". Teratol, 1987; 35: 269-275.
4. Pinnock C, Alderman Ch P: "The potential for teratogenicity of vitamin A and its congeners". The Medical Journal of Australia, 1992; 157: 804-809.
5. Laurence KM: "Prevention o f Neural Tube Defects by Improvement in maternal diet and Preconceptional Folie Acid Suppléméntatión". Prevention o f Physical and Mental Congenital Defects, Part B; Epydemiology, Early Detection and Therapy, and Environmental Factors, 1985; 383-388.
6. Laurence KM, Campbell H, James N: "The role o f improvement in maternal diet and Preconceptional Folie Acid .Supplementation in the Prevention of neural Defects. In Dobbing J, eds: "Prevention of Spina Bifida and other Neuronal Tube Defects" London: Academic Press, 1983; 85-106.
7. Godfrey PO, Erickson JD: "Vitamin A and Birth Defects. Continuing Caution is Needed." N. Engl J Med, 1995; 21(333): 1414-1415.
8. USA: Recommendations for the use of folie acid to reduce the riumber o f cases o f spina bifida and other neural tube defects. MMWRB Morb Mortal Wkly Rep, 1987; 36: 80-82.
9. USA: Department o f health and Human Semces, Public Health Service, Center for Disease Control. Recommendations for the use of folie acid to reduce the number o f cases o f spine bifida and other neural tube defects. MMWR, 1 9 92;41:1-7.
10. Pérez-Escamilla R: " Periconcéptional Folie Acid and Neural Tube Defects: Public Health Issues". Bulletin od PAHO, 1995;. 29(3): 250-259.
11. Rothman K, Moore L, Singer M, et al. "Teratogenicity of High Vitamin A Intake". N Engl J Med, 1995; 21(333): 1369-1373.
12. Xui-Dao D, Chen A, Reidy J, ét al: "Folie acid and chromosome breakage". MutationRes, 1986; 174: 115-119.
13. Wald NJ, Hackshaw AK, Stone R, Nefertriti A: "Blood folie acid a,nd vitamin B12 in relation to neural tube defects" Br J Obstet Gynaecol, 1996; 103: 319- 324.
14. Blot L, Rey A, Kaltwasser JP, et al: "Folate and Iron Deficiencies in Mothers andThéir Newbom Children". Matemo-fetal Relations in Iron and Foliate Deficiencies. Springer-Verlag, 1982; 297-303.
15. Gillberg Ch, Wahlstrom J, Johansson R, et al: "Folie Acid as an adjunct in the treatment o f children with the autism fragile-X syndroffie :(ApRAX)". Developmental Mediciñe árid Child Ñeurology, 1986; 28: 624-627.
16. Blot L, Papiemik E, Kaltwasser JP, Wemer E, Techemia G: "Influence of routine administration o f folie acid and iron during pregnancy". Gynecol Obstet Invest, 1981; 12: 294.
17. Baumslag N, EdelsteinT, Metz J: "Reduction of incidence o f prematurely by folie acid supplementation in pregnancy". Br Med J, Í970; 1: 16.
18. Wolbach SB, Howe PR: "Tissue changes Following deprivation o f fat soluble A vitamin". J Exp Med, 1925; 42: 753-777.
19. Chytil F: "The lungs and vitamin A". A. Am J Physiol, 1992; 262: 517-527.
20. Studer M, Poperl H, Marshall H, et al: " Role of a conserved retinoic acid response element in rhombomere restriction o f Hoxb-l'\ Science, 1994; 265: 728-1732.
21. Bigby M, Stem RS: "Adverse reactions to isotretionin". J Am Acad Dermatol, 1988; 18: 543-552.
22. Waíren EW, Kinandera U: "Use o f retinoids in the treatment o f psoriasis". Clin Pharm, 1989: 8: 344-351.
23. Lucek RW, Colbum WA: "Clinical pharmocokinetics o f the retinoids". Clin Pharmacokinétic, 1985; 10: 38-62.
24. Geeleñ JA: "Hypervitaminosis A induced teratogenesis. CRC; Crit Rev Toxicol, 1979; 6: 351-375.
25. Jarvis BL, Johnston MC, Sulick KK: "Congenital malformations of the external middle an inner earproduced by isotretionin exposure in mouse embryos". Otolaryngol Head Neck Surg, 1990; 102: 391-401.
26. Da Costa D, de Fária G, Dias J, Bariani R: Acao Teratogena de Hipervitaminose A, com especial enfase sobre o globo ocular erri fetos.de ratos". Revista Goiana de Medicina, 1991; 37: 15-22.
27. Brentegani L, Sala M, Lopes R: "Estudio morfométrico y estereólógico de las alteraciones provocadas por hipervitaminosis A eb la glándula submandibular del hámster". Rev Fac Farm Odont Rib Preto, 1987; 144-147.
28. ILADIBA: "Exceso de vitamina A se asocia con desarrollo de de defectos congénitos", 1995; 63.
29. Vogt HJ, Ewers R: "13-cis-retinoic acid and spermatogenesis investigations by spermatólogy and impulse cytophotometry". Hautartz, 1985; 36: 281-286.
30. Rosa FW: "Teratogenicity of Isotretionin". Lancet, 1983; 2; 513.
31. Lammer E, Chen D, Hoar R, et al: "Retinoic acid embryophaty". N Engl J Med, 1985; 313: 837-841.
32. Doering PL, Araujo OE, Frohnapple DJ, et al: "Pattems o f prescribing isotretionin: focus on women of childbeanng potential". Ann Pharmacother,1992; 26: 155-161.
33. Stem RS: "When a uniquely effective drug is teratogenic. The case o f isotretionin". N Engl J Med, 1989; 320: 1007-10Ó9.
34. Alarcón M, Jonckree M, Sánchez de Molina D, cois: "Modificaciones dél Metabolismo proteico en la hipervitaminosis A aguda, en ratas". Acta Cient, 1986; 37(2): 162-169.
35. Nelsoñ M: (editorial). "Vitamina A liver consumption and risk of birth defecls". BMJ, 1990; 301: 1176.
36. Camera G, Pegfiasco P: "Ear malformation in baby bomto mother using tretinoin cream (letter)". Lancet, 1982; 339: 687.
37. Lammer EJ: "Embryóphathy in an infant conserved oné year after termination of maternal etretinate". Lancet 1988; 2: 1080-1081.
38. Martiñez-Frias ML, Salvador J: "Epidemiological aspeets o f prenatal exposure to high doses of Vitamin A in Spain". Eur J Epidemiol, 1990; 6: 118-123.
39. Werler MM, Lammer EJ, Rosenberg, L, Mitchel AA: "Maternal vitamin A supplementation in relation to selected birth defects". Teratology, 1990; 42: 497-503.
40. Choo V: "High-dose retinol associated with birth defects". Lancet, 1995; 36: 1027.
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Publicado
2017-06-09
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1.
López R, Sáenz K, Torres C. Vitamina "A" y riesgos de teratogenicidad. Rev Fac Cien Med (Quito) [Internet]. 9 de junio de 2017 [citado 19 de diciembre de 2024];22(1):9-11. Disponible en: https://revistadigital.uce.edu.ec/index.php/CIENCIAS_MEDICAS/article/view/837
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