Endogenous Interleukin-12 regulates macrophage phagocytosis of Sporothrix schenckii
Resumen
Context: Sporothrix shenckii is a widespread dimorphic fungus that causes sporotrichosis, an acute and chronic infection of the skin and subcutaneous tissues. It displays a range of clinical forms from fixed cutaneous to systemic infection[1]. Systemic sporotrichosis occurs mainly in immunodeficient patients and can be potentially fatal [2]. In the host defense against S. schencki, macrophages play an important role [3-5] through both phagocytosis and oxidative processes
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1. Morris-Jones R. Sporotrichosis. Clin Dermatol 2002; 27: 427 – 31.
2. Silva-Vergara ML, Maneira FR, De Oliveira RM, Santos CT, Etchebehere RM, Adad SJ. Multifocal sporotrichosis with meningeal involvemente in a patient with AIDS. Med Mycol 2005; 43(2): 187 – 90.
3. Oda LM, Kubelka CF, Alviano CS, Travassos R. Ingestión of Yeast Forms of Sporothrix schenckii by Mouse Peritoneal Macrophages. Infect Immun 1983; 39: 497 – 504.
4. Tachibana T, Matsuyama T, Mitsuyama M. Involvement of CD4+ T cells and macrophages in acquired protection against infection with Sporothrix schenckii in mice. Med Mycol 1999; 37: 397 – 404.
5. Fernandes KSS, Coelho AL, Lopez-Becerra LM, Barja- Fidalgo C. Virulence of Sporothrix schenckii conidia and yeast cells, and their susceptibility to nitric oxide. Immunology 2000; 101: 563 – 69.
6. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13: 251 – 76.
7. Puddu P, Fantuzzi L, Borghi P, Varano B, Rainaldi G, Guillemard E, et.al. IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages. J Immunol 1997; 159: 3490 – 97.
8. Trinchiery G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133 – 46.
9. Zhoou P, Sieve MC, Bennett J, Kwon-Chung KJ, Tewari RP, Gazzinelli RT, et.al. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J Immunol 1995; 155: 785 – 95.
10. Magee DM, Cox RA. Interleukin-12 regulation of host defenses against Coccidioides immitis. Infect Immun 1996; 64: 3609 – 13.1
2. Silva-Vergara ML, Maneira FR, De Oliveira RM, Santos CT, Etchebehere RM, Adad SJ. Multifocal sporotrichosis with meningeal involvemente in a patient with AIDS. Med Mycol 2005; 43(2): 187 – 90.
3. Oda LM, Kubelka CF, Alviano CS, Travassos R. Ingestión of Yeast Forms of Sporothrix schenckii by Mouse Peritoneal Macrophages. Infect Immun 1983; 39: 497 – 504.
4. Tachibana T, Matsuyama T, Mitsuyama M. Involvement of CD4+ T cells and macrophages in acquired protection against infection with Sporothrix schenckii in mice. Med Mycol 1999; 37: 397 – 404.
5. Fernandes KSS, Coelho AL, Lopez-Becerra LM, Barja- Fidalgo C. Virulence of Sporothrix schenckii conidia and yeast cells, and their susceptibility to nitric oxide. Immunology 2000; 101: 563 – 69.
6. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13: 251 – 76.
7. Puddu P, Fantuzzi L, Borghi P, Varano B, Rainaldi G, Guillemard E, et.al. IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages. J Immunol 1997; 159: 3490 – 97.
8. Trinchiery G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133 – 46.
9. Zhoou P, Sieve MC, Bennett J, Kwon-Chung KJ, Tewari RP, Gazzinelli RT, et.al. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J Immunol 1995; 155: 785 – 95.
10. Magee DM, Cox RA. Interleukin-12 regulation of host defenses against Coccidioides immitis. Infect Immun 1996; 64: 3609 – 13.1
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2017-05-29
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Flores García A, Fernandez Argüelles R, Barba Barajas M, Velarde Félix S, Fernandez Argüelles R. Endogenous Interleukin-12 regulates macrophage phagocytosis of Sporothrix schenckii. Rev Fac Cien Med (Quito) [Internet]. 29 de mayo de 2017 [citado 22 de noviembre de 2024];35(1):59-60. Disponible en: https://revistadigital.uce.edu.ec/index.php/CIENCIAS_MEDICAS/article/view/1062
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