Medicación preanestésica con clonidina
Resumen
Clonidina, droga alfa-2-adrenérgica actúa en receptores de la médula oblongada, presinápticamente en las terminaciones nerviosa periféricas y receptores a nivel central para causar una reducción de la actividad del sistema nervioso simpático.
Está usándose coi-" o premedicación para proveer sedación y ansiólisis y mejorar las cualidades de la inducción, mantenimiento y recuperación de la anestesia.
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1. Carabine, U.A., Wirght, P.M.C. and Moore, J . : Preanaesthetic edication with Clonidine: A dose-response study. British Journal of Anaesthesia, 1991; 67: 79-93.
2. Maze, M., Segal, I . , Bloor, BC : Clonidine and other alpha 2 adrenergic agonists: Strategies for the rational use of these novel agents. Journal of Clinical Anaesthesia, 1988; 1:146-157.
3. Ghignone, M., Quintín, L . , Duke, P C , Kehler, CH., Calvillo, O.: Effects of clonidine on narcotic requeriment and hemodynamic responses during induction of fentanyl anethessia and endotracheal intubation. Anesthesiology, 1986; 64: 36-42.
4. Bloor, B C , Flacke, WE : Reduction in halothane anesthetic requeriments by clonidine, and alpha adrenergic agonist. Anestehsia and Analgesia, 1982; 61: 741-745.
5. Flacke, JW , Bloor, B C , Flacke, WE.: Reduced narcotic requeriments by clonidine with improved hemodynamics and adrenergic stability in patients undergoing coronay bypass surgery. Anesthesiology, 1987;67:11-19.
6. Wright, P.M.C, Carabine, U.A., McClune, D.A, and Moore, J . : Preanaesthetic Medication with Clonidine. British Journal of Anaesthesia, 1990; 65: 628-632.
7. Wing, LMH., Reid, J L . , Hamilton, CA., Sever, P , Davies, DS., Dollery, CT.: Effects of clonidine on biochemical Indices of sympathetic function and plasma renin activity in normotensive man. Clinical Science, 1977; 53: 45-53.
8. Woodcock, TE., Millard, RK., Dixon, J . , Prys Roberts, C : Clonidine premedication for isoflurane-induced hypotension. British Journal of Anaesthesia, 1988; 60:
388-394.
9. Bellaiche, S., et all.: Clonidine does not delay recovery from anaesthesia. British Journal of Anaesthesia, 1991; 66: 353-357.
10. Angelí, A., Majeed, ABA... .Alterations of "sleeping time" in the rat induced by drugs which modulate central monaminergic systems. British Journal of Anaesthesia, 1990;64; 594-600.
11. Richards, MJ., Skue?. .MA.. Jarais. .AP., Prys-Roberts, C, Total IV anaesthesia with propofol and alfentanil: Dose requeriments for propoíoi and ihe effect of premedication with clonidine. British Journal of .Anaesthesia, 1990; 65: 157-163.
12. Maze, M., Ross, ChB.. Vickery. RG., Merlone, S C , Gaba, DM.: Anesthetic ar.c hemodynamic effects of the alpha-2-adrenergic agonist, azepexole: in isoflurane-anesthetized dogs, Anesthesiology, 1988; 68: 689-694,
13. Quintín, L . , Buda. M., Hilaire, G.. Bardelay, C , Ghignome, M,, Pujol, JF.: Catecholamine metabolism in the rat locus coeruleus as studied by in nvo differential pulse voltammetry. I I I Evidence :or existence of an alpha 2 adrenergic tonic inhibition i.n behaving rat. Brain Research, 1986: 375: 235-245
14. Delaunay, L , , Bonnet. F,. and Duvaldesting, P : Clonidine decreases postoperative osygen comsumption in patients recobery from general anaesthesia. British Journal of Anaesthesia, 1991: 67 ; 397-401.
15. Bay, J , , Nunn, J F . . Prys Roberts, C ; Factors influencing arterial P02 during recovery- from anaesthesia. British Journal of Anaesthesia. 1988: 40: 398-407.
16. Ciofolo, MJ., Clereue. F.. Devilliers, C , Ben Ammar, M., Viars, P.: Changes in ventüation oxygen uptake and carbón dioxide output during recovery from isoflurane anesthesia, Anesthesiology. 19o9;7ü: 737-741.
17. Goldfarb, G., Ang. ET.. Debaene. B., Khon, S,, Jolis, P, Effect of clonidine on posoperative shivering in man. A double-biind study. .Anesthesiology, 1989; 71: A 659.
18. Quintín, L . , et all.: Eftec; oí clonidine on the circulation and vasoactive hormones aither aortic surgery. British Journal of .Anaesthesia. 1991:66: 108-115.
19. Miller, R.D,: Progundidac ce la .Anestesia y CAM En: Cullen, D.J.: .Anestesia, Barcelona, E. Doyma, I , 529, 1988.
20. Miller, R.D.: .Anestesia en Cirugía Vascular. En: Clark,, N,J,, y Stanley, T.H.: Anes:esia. Barcelona, Ed. Doyma, II 1421, 1988".
21. Miller, R.D.: La Anestesia en algunas enfermedades de valoración y Tratamiento especiales. En: Roizen, M,F. Anestesia. Barcelona, Ed. Do>-ma, I , 304, 1988.
22. Woodcock, T, E , , et al!,: Conodine premedication for isoflurane induced hipotensión, British Journal of Anaesthesia, 1988; 60: 38S-394.
23. Ghignone, M., Gavillo, O., Caple, S,, Quintín, L : Clonidine reduces the dose requeriment for nitroprusside induced hypotension, .Anesthesiology, 1986; 65: A 51,
24. Newman, B,, Gelb, AW.. Lam, .AM,: The effect of isoflurane induced hypotension on cerebral blood flow and cerebral metabolic rate for oxygen in humans. Anesthesiology, 1986; 64: 307-310,
25. Simpson, DL., MacRae, WR,, Willsmith, JAW,, Dale, AB.: Acute Beta-adrenoceptor blockade and induced hypotension. Anaesthesia, 1987; 42: 243-248.
26. Rudd, P., Blaschke, T F , : Agentes antihipertensivos y drogas para terapia de hipertensión. En: Gilman, AG., Goodman, LS., Rail, TW., Murad, F . : Bases Farmacológicas de tratamiento. New York, Ed. Goodman y Gilman's, 790-792, 1985.
27. Pereira, E., Millar, RK,, Hutton, P.: Intraoperative arterial pressure regulation using adaptive closed-loop control with sodium nitroprusside. British Journal of Anaesthesia, 1986; 58: 815-816.
28. Pereira, E , , Millar, RK,, Prys-Roberts, C , Hutton, P The use of phenylephrine in the adaptive closed-loop control of blood pressure, British Journal of Anaesthesia, 1986;58: 816.
29. López Alonso, G.: Fundamentos de Anestesiología. 3a. Ed, 310.
30. Byron, C , Bloor, PhD,: Clonidine and other alpha-2- adrenergic agonist: and important new Drug Class for the perioperative period, Seminars in Anesthesia. 1988: Vn (3): 170-177.
31. Glynn, C, J . , Teddy, P, J , Role of Spinal Noradrenergic System in Transmission of Pain in patients with Spinal Cord Injury. The Lancet, 1986; Nov. 29.
32. Miller, R., Savarese, J . , Covino, B.: Farmacología Básica y Clínica de los Fármacos Anestésicos Locales, Aneste sia, 2a, Ed. Vol, 2: 29.
33. Yakash, TL., Hammond, DI.: Peripheral and central substrates involved in the rostrad transmission of nociceptive Information. Pain, 1982; 13: 1-85.
34. Castro, MI., Eisenach, J C : Pharmacokinetics and Pharmacodynamics of Intrathecal, Epidrual and Intravenous Clonidine in sheep. Anestehsiology, 1989; 71: 418-425.
35. Dollery, CT., et all: Clinical Pharmacology and Pharmacokinetics of Clonidine, Clinical Pharmacology and Therapeutics, 1976; 19: 11-17.
36. Reid, JL, The clinical pharmacology of clonidine and related central anti-hipertensive agents, British Journal of Clinical Pharmacology, 1981; 12: 206-302.
37. Svensson, TH,, Bunney, BS., Aghajanian, GK,: Inhibition of both noradrenergic and serotonergic neurons in brain by alpha 2 agonist clonidine. Brain Research, 1986; 92: 291-306.
38. Unnerstall, JR., Kopajtic, JA., Kuhar, MJ.: Distribution of alpha 2 agonist binding sites in the rat and humans CNS: Analysis of some functional anatomic correlatos of the pharmacologic effects of clonidine and related adrenergic agents. Brain Research, 1984; 319: 69-101.
39. Vickery, RG., Sheridan, B C , Segal, IS., Maze, M.: Anesthetic and hemodynamic effects of the stereoisomers of medetomidine an alpha-2-adrenergic agonist in halothane anesthetized dogs, Anesthesia and Analgesia, 1988; 67: 611-615.
40. Aukburg, SJ., Geer, RT., WoUman, H., Neufeld,' GR. Errors in measurementt of oxygen uptake due to anesthetic gases. Anesthesiology, 1985; 62: 54-59.
41. Newberg, LA., Milde, JH , Michenfelder, JD.: Systemic and cerebral effects of isoflurane-induced hypotension in dogs, Anesthesiology, 1984; 60: 541-546.
2. Maze, M., Segal, I . , Bloor, BC : Clonidine and other alpha 2 adrenergic agonists: Strategies for the rational use of these novel agents. Journal of Clinical Anaesthesia, 1988; 1:146-157.
3. Ghignone, M., Quintín, L . , Duke, P C , Kehler, CH., Calvillo, O.: Effects of clonidine on narcotic requeriment and hemodynamic responses during induction of fentanyl anethessia and endotracheal intubation. Anesthesiology, 1986; 64: 36-42.
4. Bloor, B C , Flacke, WE : Reduction in halothane anesthetic requeriments by clonidine, and alpha adrenergic agonist. Anestehsia and Analgesia, 1982; 61: 741-745.
5. Flacke, JW , Bloor, B C , Flacke, WE.: Reduced narcotic requeriments by clonidine with improved hemodynamics and adrenergic stability in patients undergoing coronay bypass surgery. Anesthesiology, 1987;67:11-19.
6. Wright, P.M.C, Carabine, U.A., McClune, D.A, and Moore, J . : Preanaesthetic Medication with Clonidine. British Journal of Anaesthesia, 1990; 65: 628-632.
7. Wing, LMH., Reid, J L . , Hamilton, CA., Sever, P , Davies, DS., Dollery, CT.: Effects of clonidine on biochemical Indices of sympathetic function and plasma renin activity in normotensive man. Clinical Science, 1977; 53: 45-53.
8. Woodcock, TE., Millard, RK., Dixon, J . , Prys Roberts, C : Clonidine premedication for isoflurane-induced hypotension. British Journal of Anaesthesia, 1988; 60:
388-394.
9. Bellaiche, S., et all.: Clonidine does not delay recovery from anaesthesia. British Journal of Anaesthesia, 1991; 66: 353-357.
10. Angelí, A., Majeed, ABA... .Alterations of "sleeping time" in the rat induced by drugs which modulate central monaminergic systems. British Journal of Anaesthesia, 1990;64; 594-600.
11. Richards, MJ., Skue?. .MA.. Jarais. .AP., Prys-Roberts, C, Total IV anaesthesia with propofol and alfentanil: Dose requeriments for propoíoi and ihe effect of premedication with clonidine. British Journal of .Anaesthesia, 1990; 65: 157-163.
12. Maze, M., Ross, ChB.. Vickery. RG., Merlone, S C , Gaba, DM.: Anesthetic ar.c hemodynamic effects of the alpha-2-adrenergic agonist, azepexole: in isoflurane-anesthetized dogs, Anesthesiology, 1988; 68: 689-694,
13. Quintín, L . , Buda. M., Hilaire, G.. Bardelay, C , Ghignome, M,, Pujol, JF.: Catecholamine metabolism in the rat locus coeruleus as studied by in nvo differential pulse voltammetry. I I I Evidence :or existence of an alpha 2 adrenergic tonic inhibition i.n behaving rat. Brain Research, 1986: 375: 235-245
14. Delaunay, L , , Bonnet. F,. and Duvaldesting, P : Clonidine decreases postoperative osygen comsumption in patients recobery from general anaesthesia. British Journal of Anaesthesia, 1991: 67 ; 397-401.
15. Bay, J , , Nunn, J F . . Prys Roberts, C ; Factors influencing arterial P02 during recovery- from anaesthesia. British Journal of Anaesthesia. 1988: 40: 398-407.
16. Ciofolo, MJ., Clereue. F.. Devilliers, C , Ben Ammar, M., Viars, P.: Changes in ventüation oxygen uptake and carbón dioxide output during recovery from isoflurane anesthesia, Anesthesiology. 19o9;7ü: 737-741.
17. Goldfarb, G., Ang. ET.. Debaene. B., Khon, S,, Jolis, P, Effect of clonidine on posoperative shivering in man. A double-biind study. .Anesthesiology, 1989; 71: A 659.
18. Quintín, L . , et all.: Eftec; oí clonidine on the circulation and vasoactive hormones aither aortic surgery. British Journal of .Anaesthesia. 1991:66: 108-115.
19. Miller, R.D,: Progundidac ce la .Anestesia y CAM En: Cullen, D.J.: .Anestesia, Barcelona, E. Doyma, I , 529, 1988.
20. Miller, R.D.: .Anestesia en Cirugía Vascular. En: Clark,, N,J,, y Stanley, T.H.: Anes:esia. Barcelona, Ed. Doyma, II 1421, 1988".
21. Miller, R.D.: La Anestesia en algunas enfermedades de valoración y Tratamiento especiales. En: Roizen, M,F. Anestesia. Barcelona, Ed. Do>-ma, I , 304, 1988.
22. Woodcock, T, E , , et al!,: Conodine premedication for isoflurane induced hipotensión, British Journal of Anaesthesia, 1988; 60: 38S-394.
23. Ghignone, M., Gavillo, O., Caple, S,, Quintín, L : Clonidine reduces the dose requeriment for nitroprusside induced hypotension, .Anesthesiology, 1986; 65: A 51,
24. Newman, B,, Gelb, AW.. Lam, .AM,: The effect of isoflurane induced hypotension on cerebral blood flow and cerebral metabolic rate for oxygen in humans. Anesthesiology, 1986; 64: 307-310,
25. Simpson, DL., MacRae, WR,, Willsmith, JAW,, Dale, AB.: Acute Beta-adrenoceptor blockade and induced hypotension. Anaesthesia, 1987; 42: 243-248.
26. Rudd, P., Blaschke, T F , : Agentes antihipertensivos y drogas para terapia de hipertensión. En: Gilman, AG., Goodman, LS., Rail, TW., Murad, F . : Bases Farmacológicas de tratamiento. New York, Ed. Goodman y Gilman's, 790-792, 1985.
27. Pereira, E., Millar, RK,, Hutton, P.: Intraoperative arterial pressure regulation using adaptive closed-loop control with sodium nitroprusside. British Journal of Anaesthesia, 1986; 58: 815-816.
28. Pereira, E , , Millar, RK,, Prys-Roberts, C , Hutton, P The use of phenylephrine in the adaptive closed-loop control of blood pressure, British Journal of Anaesthesia, 1986;58: 816.
29. López Alonso, G.: Fundamentos de Anestesiología. 3a. Ed, 310.
30. Byron, C , Bloor, PhD,: Clonidine and other alpha-2- adrenergic agonist: and important new Drug Class for the perioperative period, Seminars in Anesthesia. 1988: Vn (3): 170-177.
31. Glynn, C, J . , Teddy, P, J , Role of Spinal Noradrenergic System in Transmission of Pain in patients with Spinal Cord Injury. The Lancet, 1986; Nov. 29.
32. Miller, R., Savarese, J . , Covino, B.: Farmacología Básica y Clínica de los Fármacos Anestésicos Locales, Aneste sia, 2a, Ed. Vol, 2: 29.
33. Yakash, TL., Hammond, DI.: Peripheral and central substrates involved in the rostrad transmission of nociceptive Information. Pain, 1982; 13: 1-85.
34. Castro, MI., Eisenach, J C : Pharmacokinetics and Pharmacodynamics of Intrathecal, Epidrual and Intravenous Clonidine in sheep. Anestehsiology, 1989; 71: 418-425.
35. Dollery, CT., et all: Clinical Pharmacology and Pharmacokinetics of Clonidine, Clinical Pharmacology and Therapeutics, 1976; 19: 11-17.
36. Reid, JL, The clinical pharmacology of clonidine and related central anti-hipertensive agents, British Journal of Clinical Pharmacology, 1981; 12: 206-302.
37. Svensson, TH,, Bunney, BS., Aghajanian, GK,: Inhibition of both noradrenergic and serotonergic neurons in brain by alpha 2 agonist clonidine. Brain Research, 1986; 92: 291-306.
38. Unnerstall, JR., Kopajtic, JA., Kuhar, MJ.: Distribution of alpha 2 agonist binding sites in the rat and humans CNS: Analysis of some functional anatomic correlatos of the pharmacologic effects of clonidine and related adrenergic agents. Brain Research, 1984; 319: 69-101.
39. Vickery, RG., Sheridan, B C , Segal, IS., Maze, M.: Anesthetic and hemodynamic effects of the stereoisomers of medetomidine an alpha-2-adrenergic agonist in halothane anesthetized dogs, Anesthesia and Analgesia, 1988; 67: 611-615.
40. Aukburg, SJ., Geer, RT., WoUman, H., Neufeld,' GR. Errors in measurementt of oxygen uptake due to anesthetic gases. Anesthesiology, 1985; 62: 54-59.
41. Newberg, LA., Milde, JH , Michenfelder, JD.: Systemic and cerebral effects of isoflurane-induced hypotension in dogs, Anesthesiology, 1984; 60: 541-546.
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Publicado
2017-06-16
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1.
Montalvo A, Muñoz D, Pareja M, Vallejo A, Quezada L. Medicación preanestésica con clonidina. Rev Fac Cien Med (Quito) [Internet]. 16 de junio de 2017 [citado 19 de diciembre de 2024];19(1-4):60-3. Disponible en: https://revistadigital.uce.edu.ec/index.php/CIENCIAS_MEDICAS/article/view/787
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