Formulación de una solución antifúngica para la Preservación del Archivo Histórico de la Universidad Central del Ecuador

Abstract

The documentary conservation in recent years plays an important role in society, because it tries to recover the
historical memory, and the documentary acquis of it. One of the most prevalent and difficult problems is the
existence of fungi and its metabolic products in documents, as it potentially causes a total loss of information,
hindering the restoring process as well. The study seeks to formulate a solution to treat this fungal contamination,
using Fluconazole as an antifungal. We started by isolating fungi found in the books, followed by the use
of the pseudo-ternary diagram for the formulation of the solution of Fluconazole, and finally the effectiveness
of this formulations was evaluated by using modified microbiological techniques, obtaining a percentage
reduction on CFU of 90%, by nebulization a solution of Fluconazole at 24% and co-solvents: Water: 20%,
Methanol: 50%, Ethanol: 30%, during 15 minutes.