Fat embolism syndrome in long bone fractures, case report
DOI:
https://doi.org/10.29166/rfcmq.v47i2.3372Keywords:
Lung injury, Embolism, fat, Fractures, bone, seizures, case reportAbstract
Introduction: Fat embolism syndrome is a severe, although rare complication of major trauma. It is triggered by the passage of fat particles into the microcirculation in various organs. The characteristic triad: lung injury, petechial hemorrhage and neurological dysfunction. Its prevalence varies according to the diagnostic criteria and the triggering cause, making its early detection difficult.
Case presentation: Case 1. Patient 22 years old, male, suffered a car accident with open fracture of the right femur, tibia and fibula, surgically resolved, 5 hours after the event he suffered respiratory impairment, conjunctival, thoracic and extremity petechiae; later impaired consciousness, status epilepticus and paroxysmal sympathetic hyperactivity syndrome. Case 2. Patient 29 years old, male, suffered overturning of the vehicle in which he was traveling, suffering closed fractures of the left tibia, fibula and femur, after trauma surgery he suffered impaired consciousness, conjunctival petechiae and hypoxemia.
Diagnoses and interventions: Both patients underwent surgery for trauma resolution within 24 hours, after the appearance of neurological symptoms they underwent neuroimaging finding "star field" pattern, both received corticosteroids.
Results: Case 1 the outcome was vegetative state, Case 2 complete recovery.
Conclusion: Detection is essential to establish early treatment, to plan trauma surgery or to defer it and to estimate prognosis according to evolution. Cerebral fat embolism syndrome is a rare cause of paroxysmal sympathetic hyperactivity syndrome.
Downloads
Metrics
References
Godoy DA, Di Napoli M, Rabinstein AA. Cerebral Fat Embolism: Recognition, Complications, and Prognosis. Neurocrit Care. 2018;29(3):358–65.
https://doi.org/10.1007/s12028-017-0463-y
Vetrugno L, Bignami E, Deana C, Bassi F, Vargas M, Orsaria M, et al. Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports. Scand J Trauma Resusc Emerg Med. 2021;29(1):1–9.
https://doi.org/10.1186/s13049-021-00861-x
Kosova E, Bergmark B, Piazza G. Fat embolism syndrome. Circulation. 2015;131(3):317–20. https://doi.org/10.1161/CIRCULATIONAHA.114.010835
Caricato A, Russo G, Biasucci DG, Annetta MG. Fat embolism syndrome. Intensive Care Med. 2017;43(9):1411–2. https://doi.org/10.1007/s00134-017-4868-z
Mittal MK, Burrus TM, Campeau NG, Eckel LJ, Rabinstein AA, Wijdicks EFM. Pearls & oy-sters: Good recovery following cerebral fat embolization with paroxysmal hyperactivity syndrome. Neurology. 2013;81(14):107–10.
https://doi.org/10.1212/WNL.0b013e3182a6ca3e
Bajuri MY, Johan RR, Shukur H. Two variants of fat embolism syndrome evolving in a young patient with multiple fractures. BMJ Case Rep. 2013;1:1–5. http://dx.doi.org/10.1136/bcr-2013-008631
Villegas JD, Zapata MC, Jaramillo MC, Orozco E, Suárez JC. Un caso de síndrome de embolia grasa: tratamiento y rehabilitación neurológica y cognitiva. Biomédica. 2019;39(1):22–32. https://doi.org/10.7705/biomedica.v39i1.4438
Uransilp N, Muengtaweepongsa S, Chanalithichai N, Tammachote N. Fat Embolism Syndrome: A Case Report and Review Literature. Case Rep Med. 2018;(1):1–6.
https://doi.org/10.1155/2018/1479850
Scarpino M, Lanzo G, Lolli F, Grippo A. From the diagnosis to the therapeutic management: Cerebral fat embolism, a clinical challenge. Int J Gen Med. 2019;12:39–48. doi:10.2147/IJGM.S177407
Cantu CA, Pavlisko EN. Liposuction-induced fat embolism syndrome: A brief review and postmortem diagnostic approach. Arch Pathol Lab Med. 2018;142(7):871–5.
https://doi.org/10.5858/arpa.2017-0117-RS
Timon C, Keady C, Murphy CG. Fat embolism syndrome – A qualitative review of its incidence, presentation, pathogenesis and management. Malaysian Orthop J. 2021;15(1):1–11. https://doi.org/10.5704/MOJ.2103.001
Mellor A, Soni N . Fat embolism. Anaesthesia. 2001;56:145–54.
https://doi.org/10.1046/j.1365-2044.2001.01724.x
Shaikh N, Mahmood Z, Ghuori SI, Chanda A, Ganaw A, Zeeshan Q, et al. Correlation of clinical parameters with imaging findings to confirm the diagnosis of fat embolism syndrome. Int J Burns Trauma [Internet]. 2018;8(5):135–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30515352%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6261919
Shaikh N. Emergency management of fat embolism syndrome. Vol. 2, Journal of Emergencies, Trauma and Shock. 2009. p. 29. doi:10.4103/0974-2700.44680
Kwiatt ME, Seamon MJ. Symposium : Embolism in the Intensive Care Unit Fat embolism syndrome. Int J Crit Illn Inj Sci. 2013;3(1):64–8.
https://dx.doi.org/10.4103%2F2229-5151.109426
Balogh ZJ, Reumann MK, Gruen RL, Mayer-Kuckuk P, Schuetz MA, Harris IA, et al. Advances and future directions for management of trauma patients with musculoskeletal injuries. Lancet [Internet]. 2012;380(9847):1109–19. Available from:
http://dx.doi.org/10.1016/S0140-6736(12)60991-X
Berlot G, Bussani R, Shafiei V, Zarrillo N. Fulminant Cerebral Fat Embolism: Case Description and Review of the Literature. Case Reports Crit Care. 2018;2018:1–5. doi: 10.1155/2018/7813175
Morales-Vidal SG. Neurologic Complications of Fat Embolism Syndrome. Curr Neurol Neurosci Rep. 2019;19(3):1–7. https://doi.org/10.1007/s11910-019-0928-9
Fernández-Torre JL, Burgueño P, Ballesteros MA, Hernández-Hernández MA, Villagrá-Terán N, de Lucas EM. Super-refractory nonconvulsive status epilepticus secondary to fat embolism: A clinical, electrophysiological, and pathological study. Epilepsy Behav [Internet]. 2015;49:184–8. Available from: http://dx.doi.org/10.1016/j.yebeh.2015.04.045
Couturier C, Dupont G, Vassal F, Boutet C, Morel J. Effectiveness of Decompressive Hemicraniectomy to Treat a Life-Threatening Cerebral Fat Embolism. Case Reports Crit Care. 2019;2019:1–4. https://doi:10.1155/2019/2708734
Blokhuis TJ, Pape HC, Frölke JP. Timing of definitive fixation of major long bone fractures: Can fat embolism syndrome be prevented? Injury. 2017;48:S3–6. http://dx.doi.org/10.1016/j.injury.2017.04.015
Godoy DA, Orquera J, Rabinstein AA. Paroxysmal sympathetic hyperactivity syndrome caused by fat embolism syndrome. Rev Bras Ter Intensiva. 2018;30(2):237–43.
https://dx.doi.org/10.5935%2F0103-507X.20180035
Parizel P, Demey H, Veeckmans G, Verstreken F, Cras P, Jorens P, et al. Early Diagnosis of Cerebral Fat Embolism Syndrome by Diffusion-Weighted MRI (Starfield Pattern). Stroke. 2001;32:2942–5. https://doi.org/10.1161/str.32.12.2942
Bederman S, Bhandari M, McKee M, Schemitsch E. Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis. J can chir. 2009;52(5):386–93. ISSN:1488-2310
Bone B, Johnson D, Weigelt J, Scheinberg R. Early versus delayed stabilization of femoral fractures. A prospective randomized study. J BONE Jt Surg. 1989;71:336–40.
Pape HC. Effects of changing strategies of fracture fixation on immunologic changes and systemic complications after multiple trauma: Damage control orthopedic surgery. J Orthop Res. 2008;26(11):1478–84. https://doi.org/10.1002/jor.20697
Husebye EE, Lyberg T, Røise O. Bone marrow fat in the circulation: clinical entities and pathophysiological mechanisms. Injury. 2006;37(4 SUPPL.):S8.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Braulio Martínez Burbano, Francisco Caiza
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.