Diclofenaco más misoprostol: ¿Dos fármacos mejor qué uno?
Abstract
Con un grupo de estudiantes del pregrado de la Escuela de Medicina de la Facultad de Ciencias Médicas de la Universidad Central del Ecuador, que realizan sus prácticas clínicas a nivel hospitalario, conversábamos en algún momento sobre la fisiopatología de la úlcera gastroduódenal j surgió el aspecto referente a las implicaciones que tienen en la inismá los antiinflamatorios no esteroides (AlNEs).
Esto condujo a topar el tema de un medicamento del cual habían escuchado en el hospital y que aparentemente podría ser una útil herramienta terapéutica. Algunos de los considerandos que se abordaron con el grupo de estudiantes es lo que se comenta en las siguientes líneas.
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References
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2. Hayllar J, Bjamason I. NSAIDs, Cox-2 inhibitors, and the gut. Lancet 1995; 346: 52 L522
3. Graham DY, White RH, Moreland LW, Schubert TT, Katz R, Kaszewski R, et al: Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs. Ann Intem Med 1993; 119: 257-262
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5. Raskin JB, White RH, Jackson JE, Weaver AL, Tindall EA, Lies RB, Stanton I)S: Misoprostol dosage in the preven ti on of nonsteroidal anti-inflammatory druginduced gastric and duodenal ulcers: a comparison of three regimens. Ann Intem Med 1995; 123: 344-350
6. Misoprostol. En: Reynolds JEF, editor. Martindale. The Extra Pharmacopoeia. Thirtieth Edition. London: The Pharmaceutical Press, 1993; 1157-1158
7. González CH, Marques-Dias MJ, Kim CA, Sugayama SMM, Da Paz JA, Huson SM, Holmes LB: Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnaney. Lancet 1998;351:1624-1627
8. Anónimo: Ulcera gastroduodenal por antiinflamatorios 110 esteroides y su prevención. Butlletí groe 1997; 10: 9-12
9. Coelho HLL, Teixiera ÁC, Santos AP, Barros Forte E, Macedo Moráis S, La Vecchia C, et al: Misoprostol and illegal abortion in Fortalez, Brasil. Lancet 1993; 341: 1261-1263
10. García Rodríguez LA, Jick H: Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflaimnatory drugs. Lancet 1994;343:769-772.
11. Langman MJS, Weil J, Wainwright P, Lawson DH, Rawlins MD, Logan RFA, et al: Risks of bleeding peptic ulcers associated with individual non-steroidal antiinflammatory drugs. Lancet 1994; 343: 1075-1078.
12. Damman HG, Simon-Schultz J, Steinhoff I, Damaschke A, Schmoldt A, Sallowsky E: Differential effeets of misoprostol and ranitidine 011 the phannacokinetics of diclofenac and gastrointestinal symptoms. Br J Clin Pharmacol 1993;36:345-349
13. Rizack MA, editor: The Medical Letter. Handbook of adverse drug interactions. New York: The Medical Letter, Inc, 1995; 214
14. Karim A: Phannacokinetics of diclofenac and misoprostol when administered alone or as a combination product. Drugs 1993; 45 (Suppl 1): 7
15. Associacóes Medicamentosas. E11: Rozenfeld S, Pepe VLE, editoras. Guia Terapéutico Ambulatorial. Porto Alegre: Artes Médicas, 1992; 279-282
2. Hayllar J, Bjamason I. NSAIDs, Cox-2 inhibitors, and the gut. Lancet 1995; 346: 52 L522
3. Graham DY, White RH, Moreland LW, Schubert TT, Katz R, Kaszewski R, et al: Duodenal and gastric ulcer prevention with misoprostol in arthritis patients taking NSAIDs. Ann Intem Med 1993; 119: 257-262
4. Silverstein FE, Graham DY, Sénior JR, Davies HW, Struthers BJ, Bittinan RM, Geis GS: Misoprostol reduces serious gastrointestinal complications in patients with rlieumatóid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Aim Intem Med 1995; 123: 241-249
5. Raskin JB, White RH, Jackson JE, Weaver AL, Tindall EA, Lies RB, Stanton I)S: Misoprostol dosage in the preven ti on of nonsteroidal anti-inflammatory druginduced gastric and duodenal ulcers: a comparison of three regimens. Ann Intem Med 1995; 123: 344-350
6. Misoprostol. En: Reynolds JEF, editor. Martindale. The Extra Pharmacopoeia. Thirtieth Edition. London: The Pharmaceutical Press, 1993; 1157-1158
7. González CH, Marques-Dias MJ, Kim CA, Sugayama SMM, Da Paz JA, Huson SM, Holmes LB: Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnaney. Lancet 1998;351:1624-1627
8. Anónimo: Ulcera gastroduodenal por antiinflamatorios 110 esteroides y su prevención. Butlletí groe 1997; 10: 9-12
9. Coelho HLL, Teixiera ÁC, Santos AP, Barros Forte E, Macedo Moráis S, La Vecchia C, et al: Misoprostol and illegal abortion in Fortalez, Brasil. Lancet 1993; 341: 1261-1263
10. García Rodríguez LA, Jick H: Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflaimnatory drugs. Lancet 1994;343:769-772.
11. Langman MJS, Weil J, Wainwright P, Lawson DH, Rawlins MD, Logan RFA, et al: Risks of bleeding peptic ulcers associated with individual non-steroidal antiinflammatory drugs. Lancet 1994; 343: 1075-1078.
12. Damman HG, Simon-Schultz J, Steinhoff I, Damaschke A, Schmoldt A, Sallowsky E: Differential effeets of misoprostol and ranitidine 011 the phannacokinetics of diclofenac and gastrointestinal symptoms. Br J Clin Pharmacol 1993;36:345-349
13. Rizack MA, editor: The Medical Letter. Handbook of adverse drug interactions. New York: The Medical Letter, Inc, 1995; 214
14. Karim A: Phannacokinetics of diclofenac and misoprostol when administered alone or as a combination product. Drugs 1993; 45 (Suppl 1): 7
15. Associacóes Medicamentosas. E11: Rozenfeld S, Pepe VLE, editoras. Guia Terapéutico Ambulatorial. Porto Alegre: Artes Médicas, 1992; 279-282
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Published
2017-06-09
How to Cite
1.
Maldonado R JC. Diclofenaco más misoprostol: ¿Dos fármacos mejor qué uno?. Rev Fac Cien Med (Quito) [Internet]. 2017 Jun. 9 [cited 2024 Dec. 19];25(2):52-3. Available from: https://revistadigital.uce.edu.ec/index.php/CIENCIAS_MEDICAS/article/view/897
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OPINIÓN MÉDICA
