Prostaglandinas, endoperóxidos, tromboxanos y leucotrienos
Resumen
Es muy notable el interés que ha surgido en los últimos años en torno a un grupo de sustancias emparentadas químicamente con los ácidos grasos. Estas sustancias denominadas prostaglandinas tienen un gran potencial terapéutico y su utilización en una variedad de problemas clínicos está virtualmente descubriéndose. Es igualmente muy grande la expectativa que se ha creado en el mundo científico con relación a otras sustancias asociadas igualmente a los ácidos grasos y a las que se les conoce como endoperóxidos, tromboxanos y leucotrienes. No es poca la confusión existente en cuanto al origen, bioquímica y funciones biológicas de estos compuestos. Esta revisión es un esfuerzo pedagógico para sistematizar el conocimiento existente y para facilitar a los estudiantes el acceso a la riquísima y múltiple información disponible. (Revista de la Facultad de Ciencias Médicas, 8:163,1983).
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1. Samuelsson, B.: On the incorporation of oxygen in the conversión of 8, 11, 14, eicosatrienoic acid to prostaglandins E l. /. Am. Chem. Soc. 87:3011,1965
2. Hamberg, M. and Samuelsson, B.: Detection and isolation of an endoperoxide intermedíate in prostaglandin biosynthesis. Proc. Nati. Acad. acid to prostaglandins E l ./ . Am. Chem. Soc.
3. Hamberg, M.: Proc. Nati. Acad. Sci USA 71- 345,1974.
4. Hamberg, M., Hedquist, P., and Strandberg, K.: Prostaglandin endoperoxides IY. Effects on smooth muscle. Life Sci. 16: 451, 1975.
5. Von Euler, S.: Arch. Exp. Path. uPharmakolv 175:78,1934.
6. Von Euler, S.:J. Physiol., London,88:213,1937.
7. Kurzrok, R. and Lieb, C.: Biochemical studies of human semen. Procedings of the society for experimental biology. New York, 28: 268,1930.
8. Goldblatt, W.: /. Physiol, London, 84:208,1937.
9. Berstrom, S.: Chemistry of prostaglandin. Nordisk Mediciné, 42: 1456,1949.
10. Berstrom, S., and Sjovall, J.: The isolation of prostaglandins. Acia Chem. Scand., 11: 1086, 1957.
11. Naranjo, O.: Prostagalandinas. Terapial: 7,1977.
12. Labadie, P.: Les prostaglandines substances ubiquitaires. Revue du Practicien, 21: 5004, 1971.
13. Higgins, C. B. and Braunwald, E.: The prostaglandins physiologic and clinical consideration. Am.J. Med., 53: 92,1972.
14. Anderson, N. and Ramwell, E.: Biological aspects of prostaglandins Arch. Int. Med., 133: 30, 1974.
15. Loginov, A. and Markova, M.: Prostaglandins in liver diseases. Materia Médica Polona., 39:91,1979.
16. Sweatman, W. and Collier, H.: Antagonism by fenamates of prostaglandins F2 alpha and of slow reactin substance on human bronchial muscle. Nature, 219: 864,1968.
17. Butcher, R.: Symposium on Prostaglandins. Ed. Ramwell & Shaw Interscience Publ., New York,1968.
18. Lichtenstein, L. and Bernardo, E.: The inmediate allergic responsin in vitro separation of antigen activation, decay and histamine release. J. Inmunol, 107:1122,1971.
19. Pike, J. and Weeks, O.: Bibliography of prostaglandins. Ed. Epjohn, USA, 1973.
20. Tauber, A. and Kaliner, M.: Inmunologic release of histamine and slow reacting substance of anaphylasis from human lung. V. Effects of prostaglandins on release of histamine. J Inmunol, 111: 27,1973.
21. Makano, J.: The prostaglandins. Ed. Ramwell, New York, 1973.
22. Frey, H. and Shaffer, A.: J. Pharmacol, 29: 267,1974.
23. Kadowitz, P., Joiner, P., and Hyman, A.: Physiological and pharmacological roles of prostaglandins. Ann. Rev. Pharmacol., 15: 285, 1975.
24. Mather, 0.: Acta Physiol. Scand., 34: 1, 1976.
25. Homes, W.•JProstaglandins Symposium Ed. Ramwell & Shaw, Interscience Publ., 1960.
26. Coceani, F.: Prostaglandins and the central nervous systems . Arch. Int. Med., 133: 119, 1974.
27. Samuelsson, B.: Prostaglandins and related factors. Synthesis or tritium—labeled prostaglandin El and studies on its distribution and
excretion in the rat. J. Biol. Chem., 239: 4091,1964.
28. Anngard, E. and Samuelsson, B.: Biosinthesis of prostaglandin from arachidonic acid in guinea pig lung. Prostaglandins and related factors 38. J. Biol. Chem., 240: 3518, 1965
29. Von Euler, S. and Ekiasson, R.: Prostaglandin. Ed. Academic Press, New York, 1967.
30. Op. Cit. 11
31. Hamberg, M., and Samuelsson, B.: Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Nati. Acad.Sci. USA,71: 34000,1974.
32. Moneada, S., Grylewski, R., Bunting, S. and Vane, J.: Nature, 263: 663,1976.
33. Grylewski, R., Bunting, S., Moneada, S., Fíower, R., and Vane, J.: Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins, 12:685,1976.
34. Moneada, S., Grilewski, R., Bunting, S. and Vane, J.: A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevent platelet agregation. Prostaglandins, 12: 715, 1976»
35. Moneada, S., Higgse, E., and Vane, J.: Human arterial and venous tissues generates prostaglandin (Prostaglandin X). A potent inhibitor of platelet agregation, Lancet, 1: 18,1977
36. Masironi, S. y otros: Calcium content of river water, trace elements concentration in toenails and blood pressuere in village population in New Guinea ScL Total Environ., 6: 41, 1976.
37. Lands, W.: The biosynthesis and metabolism of prostaglandins. Ann. Rev. Physiol., 41: 633,1979.
38. Belizan, J. and Villar, J.: The relationship between calcium intake and edemea—proteinuria and hypertension gestosis: An Hypothesis Am.J. Clin. Nut., 33:2202,1980.
39. Zámorano, B., y col.: A prostaglandin mechanism may contribute to the regulation of blood pressure in sponteneusly hipertensive rats during pregnaney, Adv. Prostaglandin Tromboxane Res., 7: 803,1980.
40. Betteridge, Á.: Role of Ca2 and ciclyc nucleotides in control of prostaglandin E production in the rat anterior pituitary gland. Biochem. 186:987,1980.
41. Roberts, S. and Scheinmnann, F.: New Synthetic routes to prostaglandins and tromboxanes. Ed. Academic Press, New YOrk, 1982.
42. Samuelsson, B. and Hammarstron, S.: Nomenclature for leukotrienes Prostaglandins, 19: 645, 1980.
43. Samuelsson, B. y otros: Advances in prostaglandin and tromboxane Research. Ed. Raven Press, New YOrk, 1980.
44. Feldberg, W., and Kellaway, J.: Physiol., 94: 187,1938.
45. Op. Cit. 43.
2. Hamberg, M. and Samuelsson, B.: Detection and isolation of an endoperoxide intermedíate in prostaglandin biosynthesis. Proc. Nati. Acad. acid to prostaglandins E l ./ . Am. Chem. Soc.
3. Hamberg, M.: Proc. Nati. Acad. Sci USA 71- 345,1974.
4. Hamberg, M., Hedquist, P., and Strandberg, K.: Prostaglandin endoperoxides IY. Effects on smooth muscle. Life Sci. 16: 451, 1975.
5. Von Euler, S.: Arch. Exp. Path. uPharmakolv 175:78,1934.
6. Von Euler, S.:J. Physiol., London,88:213,1937.
7. Kurzrok, R. and Lieb, C.: Biochemical studies of human semen. Procedings of the society for experimental biology. New York, 28: 268,1930.
8. Goldblatt, W.: /. Physiol, London, 84:208,1937.
9. Berstrom, S.: Chemistry of prostaglandin. Nordisk Mediciné, 42: 1456,1949.
10. Berstrom, S., and Sjovall, J.: The isolation of prostaglandins. Acia Chem. Scand., 11: 1086, 1957.
11. Naranjo, O.: Prostagalandinas. Terapial: 7,1977.
12. Labadie, P.: Les prostaglandines substances ubiquitaires. Revue du Practicien, 21: 5004, 1971.
13. Higgins, C. B. and Braunwald, E.: The prostaglandins physiologic and clinical consideration. Am.J. Med., 53: 92,1972.
14. Anderson, N. and Ramwell, E.: Biological aspects of prostaglandins Arch. Int. Med., 133: 30, 1974.
15. Loginov, A. and Markova, M.: Prostaglandins in liver diseases. Materia Médica Polona., 39:91,1979.
16. Sweatman, W. and Collier, H.: Antagonism by fenamates of prostaglandins F2 alpha and of slow reactin substance on human bronchial muscle. Nature, 219: 864,1968.
17. Butcher, R.: Symposium on Prostaglandins. Ed. Ramwell & Shaw Interscience Publ., New York,1968.
18. Lichtenstein, L. and Bernardo, E.: The inmediate allergic responsin in vitro separation of antigen activation, decay and histamine release. J. Inmunol, 107:1122,1971.
19. Pike, J. and Weeks, O.: Bibliography of prostaglandins. Ed. Epjohn, USA, 1973.
20. Tauber, A. and Kaliner, M.: Inmunologic release of histamine and slow reacting substance of anaphylasis from human lung. V. Effects of prostaglandins on release of histamine. J Inmunol, 111: 27,1973.
21. Makano, J.: The prostaglandins. Ed. Ramwell, New York, 1973.
22. Frey, H. and Shaffer, A.: J. Pharmacol, 29: 267,1974.
23. Kadowitz, P., Joiner, P., and Hyman, A.: Physiological and pharmacological roles of prostaglandins. Ann. Rev. Pharmacol., 15: 285, 1975.
24. Mather, 0.: Acta Physiol. Scand., 34: 1, 1976.
25. Homes, W.•JProstaglandins Symposium Ed. Ramwell & Shaw, Interscience Publ., 1960.
26. Coceani, F.: Prostaglandins and the central nervous systems . Arch. Int. Med., 133: 119, 1974.
27. Samuelsson, B.: Prostaglandins and related factors. Synthesis or tritium—labeled prostaglandin El and studies on its distribution and
excretion in the rat. J. Biol. Chem., 239: 4091,1964.
28. Anngard, E. and Samuelsson, B.: Biosinthesis of prostaglandin from arachidonic acid in guinea pig lung. Prostaglandins and related factors 38. J. Biol. Chem., 240: 3518, 1965
29. Von Euler, S. and Ekiasson, R.: Prostaglandin. Ed. Academic Press, New York, 1967.
30. Op. Cit. 11
31. Hamberg, M., and Samuelsson, B.: Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Nati. Acad.Sci. USA,71: 34000,1974.
32. Moneada, S., Grylewski, R., Bunting, S. and Vane, J.: Nature, 263: 663,1976.
33. Grylewski, R., Bunting, S., Moneada, S., Fíower, R., and Vane, J.: Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins, 12:685,1976.
34. Moneada, S., Grilewski, R., Bunting, S. and Vane, J.: A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevent platelet agregation. Prostaglandins, 12: 715, 1976»
35. Moneada, S., Higgse, E., and Vane, J.: Human arterial and venous tissues generates prostaglandin (Prostaglandin X). A potent inhibitor of platelet agregation, Lancet, 1: 18,1977
36. Masironi, S. y otros: Calcium content of river water, trace elements concentration in toenails and blood pressuere in village population in New Guinea ScL Total Environ., 6: 41, 1976.
37. Lands, W.: The biosynthesis and metabolism of prostaglandins. Ann. Rev. Physiol., 41: 633,1979.
38. Belizan, J. and Villar, J.: The relationship between calcium intake and edemea—proteinuria and hypertension gestosis: An Hypothesis Am.J. Clin. Nut., 33:2202,1980.
39. Zámorano, B., y col.: A prostaglandin mechanism may contribute to the regulation of blood pressure in sponteneusly hipertensive rats during pregnaney, Adv. Prostaglandin Tromboxane Res., 7: 803,1980.
40. Betteridge, Á.: Role of Ca2 and ciclyc nucleotides in control of prostaglandin E production in the rat anterior pituitary gland. Biochem. 186:987,1980.
41. Roberts, S. and Scheinmnann, F.: New Synthetic routes to prostaglandins and tromboxanes. Ed. Academic Press, New YOrk, 1982.
42. Samuelsson, B. and Hammarstron, S.: Nomenclature for leukotrienes Prostaglandins, 19: 645, 1980.
43. Samuelsson, B. y otros: Advances in prostaglandin and tromboxane Research. Ed. Raven Press, New YOrk, 1980.
44. Feldberg, W., and Kellaway, J.: Physiol., 94: 187,1938.
45. Op. Cit. 43.
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2017-06-16
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1.
Yépez R. Prostaglandinas, endoperóxidos, tromboxanos y leucotrienos. Rev Fac Cien Med (Quito) [Internet]. 16 de junio de 2017 [citado 15 de noviembre de 2024];8(3-4):40-54. Disponible en: https://revistadigital.uce.edu.ec/index.php/CIENCIAS_MEDICAS/article/view/527
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