Grafts, substitutes and biological mediators for periodontal regeneration in intrabony defects: an updated review
DOI:
https://doi.org/10.29166/odontologia.vol26.n2.2024-e6749Keywords:
periodontal regeneration, biocompatible materials, intrabony defectsAbstract
Objective. The objective of this narrative review is to synthesize the available evidence to provide the clinician with an updated review of biomaterials, bone grafts or substitutes, biological mediators, and other therapies used for periodontal regeneration of intrabony defects. Methodology. A search was carried out in the PubMed (Medline), PubMed, Elsevier and Google Scholar databases to extract the corresponding data. This review has analyzed and updated studies on periodontal regeneration materials. Results. The results of the present review indicate that periodontal regeneration in human intrabony defects can be achieved to a variable degree using a variety of methods and materials. Periodontal regeneration has been observed after the use of a variety of bone grafts and substitutes, guided tissue regeneration, enamel matrix derivatives that have been used and studied for some time, as well as materials that are currently emerging, such as biological mediators. Conclusion. Regenerating the insertion and support apparatus of the teeth is necessary since it allows changing or improving the prognosis after the destruction caused by periodontitis. Currently there is no biomaterial, biological mediator, graft or bone substitute that can be considered the gold standard because the use of these is only one of the factors to obtain periodontal regeneration of intrabony defects, other determinants such as the condition Systemic variables, behavioral variables, the oral environment, flap design-management techniques, and the experience and training of the surgeon also have a direct effect on the result.
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