Manejo de nuevos anticoagulantes orales en cirugía oral: revisión de literatura

Autores/as

DOI:

https://doi.org/10.29166/odontologia.vol22.n2.2020-72-91

Palabras clave:

Cirugía oral, anticoagulante, perioperatorio, protocolo clínico, hemostasia

Resumen

En el año 2011 se introdujo una nueva generación de anticoagulantes orales cuyo manejo en cirugía oral aún no está completamente esclarecido. Objetivo: El objetivo de esta revisión fue describir los protocolos existentes sobre manejo de pacientes anticoagulados en cirugía oral. Método: Se realizó una búsqueda en PubMed, SCOPUS, EBSCO y BEIC, sin límite de idioma. Resultados: Se encontraron 4781 artículos, de los cuales 19 fueron seleccionados. Conclusión: Se debe evaluar el riesgo tromboembólico y la capacidad de control de un evento hemorrágico antes de suspender el anticoagulante.

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Biografía del autor/a

Javiera Paz Mora Gómez, Universidad de los Andes

Docente de la Facultad de Odontología; Universidad de los Andes; Santiago, Chile.

Citas

Departamento de estadísticas e información de salud. Defunciones y Mortalidad por causas - DEIS, Ministerio de Salud [Internet]. [cited 2018 Oct 29]. Available from: http://www.deis.cl/defunciones-y-mortalidad-por-causas/

Turpie AGG, Reinhold Kreutz ;, Llau ; Juan, Norrving B, Haas S. Management consensus guidance for the use of rivaroxaban-an oral, direct factor Xa inhibitor. Thromb Haemost [Internet]. 2012 [cited 2018 Aug 15];108. Available from: www.thrombosis-online.com

Spyropoulos AC, Douketis JD. How I treat anticoagulated patients undergoing an elective procedure or surgery. Blood [Internet]. 2012 Oct 11 [cited 2018 Aug 17];120(15):2954–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22932800

Davis C, Robertson C. Implications of Dabigatran, a Direct Thrombin Inhibitor, for Oral Surgery Practice. J Can Dent Assoc (Tor). 2013;

Little JW. New oral anticoagulants: will they replace warfarin? Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2012 May [cited 2018 Aug 15];113(5):575–80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22668618

Romond KK, Miller CS, Henry RG. Dental management considerations for a patient taking dabigatran etexilate: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;

Van Diermen DE, Van Der Waal I, Hoogstraten J. Management recommendations for invasive dental treatment in patients using oral antithrombotic medication, including novel oral anticoagulants. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;

Fakhri HR, Janket SJ, Jackson EA, Baird AE, Dinnocenzo R, Meurman JH. Tutorial in oral antithrombotic therapy: Biology and dental implications. Med Oral Patol Oral Cir Bucal. 2013;18(3).

Pengo V. Laboratory tests during direct oral anticoagulant treatment? Yes. Intern Emerg Med [Internet]. 2013 Aug 21 [cited 2018 Aug 15];8(5):371–2. Available from: http://link.springer.com/10.1007/s11739-013-0949-3

Breik O, Cheng A, Sambrook P, Goss A. Protocol in managing oral surgical patients taking dabigatran. Aust Dent J. 2014;

Machuca-Portillo G, Cabrerizo-Merino C, Cutando-Soriano A, Giménez-Prats M-J, Silvestre-Donat F-J, Tomás-Carmona I. Consensus report of the XI Congress of the Spanish Society of Odontology for the handicapped and special patients. Med Oral Patol Oral Cir Bucal [Internet]. 2014 Sep 1 [cited 2018 Jul 19];19(5):e495-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24608224

Scott A, Gibson J, Crighton A. The Management of Dental Patients Taking New Generation Oral Anticoagulants. Prim Dent J. 2014;

CEBM. Oxford Centre for Evidence-based Medicine - Levels of Evidence (March 2009) - CEBM [Internet]. [cited 2018 Jul 28]. Available from: https://www.cebm.net/2009/06/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/

Primo J. Niveles de evidencia y grados de recomendacion (I/II). • Enferm Inflamatoria Intest al día [Internet]. 1996 [cited 2018 Jul 28];107(3S):21–35. Available from: www.cebm.net/levels_of_evidence.asp

Moraga C J, Cartes-Velásquez R. PAUTAS DE CHEQUEO, PARTE II: QUOROM Y PRISMA. Rev Chil cirugía [Internet]. 2015 Jun [cited 2018 Jul 28];67(3):325–30. Available from: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S071840262015000300015&lng=en&nrm=iso&tlng=en

Rivas-Ruiz R. Medicina basada en la evidencia. Guías de práctica clínica [Internet]. Instituto Mexicano del Seguro Social. 2014 [cited 2018 Jul 28]. Available from: https://www.researchgate.net/profile/Rodolfo_Rivas-Ruiz/publication/269631230_Medicina_Basada_en_la_Evidencia_Guias_de_practica_clinica/links/549045ff0cf214269f266469/Medicina-Basada-en-la-Evidencia-Guias-de-practica-clinica.pdf

Elm E von, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ [Internet]. 2007 Oct 20 [cited 2018 Jul 28];335(7624):806–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17947786

Pautas éticas internacionales para la investigación y experimentación biomédica en seres humanos - Universidad de Chile [Internet]. [cited 2018 Jul 28]. Available from: http://www.uchile.cl/portal/investigacion/centro-interdisciplinario-de-estudios-en-bioetica/documentos/76195/agradecimientos-y-antecedentes

Hernández V. Anticoagulantes orales en patología cardiovascular [Internet]. Vol. 11. 2011 [cited 2018 Oct 29]. Available from: http://www.clinicalascondes.cl/clcprod/media/contenidos/pdf/MED_11_1/Anticoagulantes.pdf

Steffel J, Verhamme P, Potpara T, Albaladejo P. The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Eur Soc Cardiol [Internet]. 2018 [cited 2018 Oct 27];39:1330–93. Available from: https://watermark.silverchair.com/ehy136.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAjwwggI4BgkqhkiG9w0BBwagggIpMIICJQIBADCCAh4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMLThTh2GBp-f0AvbpAgEQgIIB7yUCwvX91vCgcTkWDmRYRudOduTDfW5AvIuacW6cUg4j1t9b

Scully C. Anticoagulant update. British Dental Journal. 2013.

Kamoh A, Swantek J. Hemostasis in Oral Surgery. Dental Clinics of North America. 2012.

Pérez-Gómez F, Bover R. La nueva cascada de la coagulación y su posible influencia en el difícil equilibrio entre trombosis y hemorragia. Rev Española Cardiol [Internet]. 2007 Dec 1 [cited 2018 Jul 2];60(12):1217–9. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0300893207751965

Palta S, Saroa R, Palta A. Overview of the coagulation system. Indian J Anaesth [Internet]. 2014 Sep [cited 2018 Oct 29];58(5):515–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25535411

Curto A. The new oral anticoagulants in oral and maxillofacial surgery. Journal of Oral and Maxillofacial Surgery. 2015.

Tran H, Joseph J, Young L, Mcrae S, Curnow J, Nandurkar H, et al. New oral anticoagulants: A practical guide on prescription, laboratory testing and peri-procedural/bleeding management. Intern Med J. 2014;44(6).

Elad S, Marshall J, Meyerowitz C, Connolly G. Novel anticoagulants: General overview and practical considerations for dental practitioners. Oral Dis. 2016;

Ceresetto JM. Anticoagulantes orales directos y un cambio en el paradigma del monitoreo de la anticoagulación [Internet]. Vol. 50, Acta bioquímica clínica latinoamericana. [Federacíon de Especialistas de Análisis Biológicos de la Provincia de Buenos Aires]; 2016 [cited 2018 Jul 25]. 181-192 p. Available from: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000200003

Wahl MJ, Pinto A, Kilham J, Lalla R V. Dental surgery in anticoagulated patients - Stop the interruption. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(2).

Costantinides F, Rizzo R, Pascazio L, Maglione M. Managing patients taking novel oral anticoagulants (NOAs) in dentistry: A discussion paper on clinical implications. BMC Oral Health. 2016;

Healey JS, Eikelboom J, Douketis J, Wallentin L, Oldgren J, Yang S, et al. Periprocedural Bleeding and Thromboembolic Events With Dabigatran Compared With Warfarin: Results From the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Randomized Trial. Circulation [Internet]. 2012 Jul 17 [cited 2018 Aug 18];126(3):343–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22700854

ANEXO I FICHA TÉCNICA O RESUMEN DE LAS CARACTERÍSTICAS DEL PRODUCTO. [cited 2018 May 1]; Available from: http://www.ema.europa.eu/docs/es_ES/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf

Martinuzzo M, Duboscq C, López MS, Montenegro M, Viñuales S, Girardi B, et al. Dabigatran en plasma: tiempos de trombina diluido, Ecarin y veneno de víbora de Russell diluido [Internet]. Vol. 50, Acta bioquímica clínica latinoamericana. [Federacíon de Especialistas de Análisis Biológicos de la Provincia de Buenos Aires]; 2016 [cited 2018 Jul 25]. 193-203 p. Available from: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000200004

van Ryn J, Stangier J, Haertter S, Liesenfeld K-H, Wienen W, Feuring M, et al. Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity. 2010 [cited 2018 Aug 15]; Available from: https://pdfs.semanticscholar.org/d0a2/99c38b05380707c3226e12714860685e6bd2.pdf

Steed MB, Swanson MT. Warfarin and Newer Agents: What the Oral Surgeon Needs to Know. Oral and Maxillofacial Surgery Clinics of North America. 2016.

Syyed N, Ansell M, Sood V. Dabigatran (Pradaxa®): surgeon’s friend or foe? Br Dent J [Internet]. 2014 Dec 5 [cited 2018 Jul 21];217(11):623–6. Available from: http://www.nature.com/articles/sj.bdj.2014.1051

Miranda M, Martinez LS, Franco R, Forte V, Barlattani A, Bollero P, et al. Differences between warfarin and new oral anticoagulants in dental clinical practice. Oral Implantol (Rome) [Internet]. 2016 [cited 2018 Jul 25];9(3):151–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28042443

Nathwani S, Wanis C. Novel oral anticoagulants and exodontia: The evidence. Br Dent J. 2017;

omez-Moreno Antonio Aguilar-Salvatierra Esther Fern andez-Cejas Rafael Arcesio Delgado-Ruiz Aleksa Markovic Jos Luis Calvo-Guirado GG, Omez-Moreno GG, Aguilar-Salvatierra A, Arcesio Delgado-Ruiz R. Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban. Clin Oral Implants Res. 2015;

CHMP. ANEXO I FICHA TÉCNICA O RESUMEN DE LAS CARACTERÍSTICAS DEL PRODUCTo XARELTO [Internet]. [cited 2018 Nov 3]. Available from: https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_es.pdf

Berkovits A, Aizman A, Zúñiga P, Pereira J, Mezzano D. Nuevos anticoagulantes orales. Rev Med Chil [Internet]. 2011 Oct [cited 2018 Apr 30];139(10):1347–55. Available from: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001000016&lng=en&nrm=iso&tlng=en

Daly C. Treating patients on new anticoagulant drugs. Aust Prescr [Internet]. 2016 Dec [cited 2018 Oct 25];39(6):205–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27996061

Faraoni D, Levy JH, Albaladejo P. Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants. Biomed Cent. 2015;

Hanken H, Gröbe A, Heiland M, Smeets R, Kluwe L, Wikner J, et al. Postoperative bleeding risk for oral surgery under continued rivaroxaban anticoagulant therapy. Clin Oral Investig [Internet]. 2016 Jul 26 [cited 2018 Jul 29];20(6):1279–82. Available from: http://link.springer.com/10.1007/s00784-015-1627-9

Mauprivez C, Professor A, Khonsari R, Professor A, Razouk O, Goudot P, et al. Management of dental extraction in patients undergoing anticoagulant oral direct treatment. A pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;

Hassona Y, Malamos D, Shaqman M, Baqain Z, Scully C. Management of dental patients taking direct oral anticoagulants: Dabigatran. Oral Dis. 2018;

All Wales Advice on the Role of Oral Anticoagulants ALL WALES ADVICE ON THE ROLE OF ORAL ANTICOAGULANTS RECOMMENDATIONS ONLY [Internet]. [cited 2018 Oct 27]. Available from: www.awmsg.org/docs/awmsg/medman/All Wales Advice on the Rol

Management of Dental Patients Taking Anticoagulants or Antiplatelet Drugs Dental Clinical Guidance Scottish Dental Clinical Effectiveness Programme SDcep [Internet]. 2015 [cited 2018 Oct 27]. Available from: http://www.sdcep.org.uk/wp-content/uploads/2015/09/SDCEP-Anticoagulants-Guidance.pdf

Lopez-Galindo M, Bag�n J V. Apixaban and oral implications. J Clin Exp Dent. 2015;

Sivolella S, De Biagi M, Brunello G, Berengo M, Pengo V. Managing dentoalveolar surgical procedures in patients taking new oral anticoagulants. Odontology. 2015;

Clemm R, Neukam FW, Rusche B, Bauersachs A, Musazada S, Schmitt CM. Management of anticoagulated patients in implant therapy: a clinical comparative study. Clin Oral Implants Res. 2016;27(10).

Daly C. Dental note: Treating patients on new anticoagulant drugs. Aust Prescr [Internet]. 2016 Dec 5 [cited 2018 Jul 22];39(6):205–7. Available from: https://www.nps.org.au/australian-prescriber/articles/treating-patients-on-new-anticoagulant-drugs

Thean D, Alberghini M. Anticoagulant therapy and its impact on dental patients: A review. Vol. 61, Australian Dental Journal. 2016.

Caliskan M, Tükel HC, Benlidayi ME, Deniz A. Is it necessary to alter anticoagulation therapy for tooth extraction in patients taking direct oral anticoagulants? Med Oral Patol Oral Cir Bucal. 2017;

Firriolo FJ, Hupp WS. MEDICAL MANAGEMENT AND PHARMACOLOGY UPDATE Beyond warfarin: the new generation of oral anticoagulants and their implications for the management of dental patients. OOOO. 2012;113:431–41.

Weitz JI, Quinlan DJ, Eikelboom JW. Periprocedural Management and Approach to Bleeding in Patients Taking Dabigatran. Circulation [Internet]. 2012 Nov 13 [cited 2018 Aug 1];126(20):2428–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23147769

Cohen H V, Quek SYP, Subramanian G, Abbas A. New antiplatelet and anticoagulant drugs. Considerations for dental patient management. J N J Dent Assoc [Internet]. 2013 [cited 2018 Nov 2];84(1):30–3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23556294

Curtin C, Hayes J, Hayes J. Dental Implications of New Oral Anticoagulants for Atrial Fibrillation. Dent Update. 2014;

Supporting local implementation of NICE guidance on use of the novel (non-Vitamin K antagonist) oral anticoagulants in non-valvular atrial fibrillation NICE Implementation Collaborative. [cited 2018 Jul 23]; Available from: https://www.nice.org.uk/guidance/cg180/resources/nic-consensus-statement-on-the-use-of-noacs-243733501

Abayon M, Kolokythas A. Dental management of patients on direct oral anticoagulants: Case series and literature review. Quintessence Int [Internet]. 2016 [cited 2018 Jul 29];47(8):687–96. Available from: http://web.b.ebscohost.com.uandes.idm.oclc.org/ehost/detail/detail?vid=0&sid=570e4205-90df-47f8-ab3e9a852b245977%40sessionmgr104&bdata=Jmxhbmc9ZXMmc2l0ZT1laG9zdC1saXZl#db=ddh&AN=118412302

Publicado

2020-07-01

Cómo citar

Mora Gómez, J. P. (2020). Manejo de nuevos anticoagulantes orales en cirugía oral: revisión de literatura. Odontología, 22(2), 72–91. https://doi.org/10.29166/odontologia.vol22.n2.2020-72-91

Número

Sección

Revisión de Literatura