Nutritional supplementation of glutamine on the productive performance in broiler chickens
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Abstract
The objective of this research was to evaluate the effect size of glutamine supplementation on the productive performance of broiler chickens, the consistency of their effect and the influence of other factors through the use of meta-analysis. It was found that glutamine supplementation favors the use of nutrients reflected in lower values of feed conversion (calculated with weight gain) 1,484 versus 1,518, and an average effect size of -0,031 (difference of means) (P = 0,00005). Control chickens require an additional 31 g of feed to produce 1 kg of weight gain compared to the group that did receive the amino acid under study. When the variable analyzed was feed conversion (calculated with live weight) (1,468 vs 1,478), it was determined that chickens without glutamine require an additional 15 g of feed to produce 1 kg of live weight (difference of means = -0,015; P = 0.00001). No consistent effect was found between the studies carried out, with high values in the inconsistency test, 100% and 81.6% for the two forms of feed conversion. The meta-regressions indicate that factors related to the design of the experiment or certain nutrient levels have an impact on the variable under study. It is concluded that glutamine supplementation favors the productive performance in broiler chickens. However, the design of the study and the formulation of the diet should be considered.
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References
Abdulkarimi, R., Shahir, M. H., & Daneshyar, M. (2019). Effects of dietary glutamine and arginine supplementation on performance, intestinal morphology and ascites mortality in broiler chickens reared under cold environment. Asian-Australasian Journal of Animal Sciences, 32(1), 110-117. https://doi.org/10.5713/ajas.17.0150
Askanazi, J., Carpentier, Y. A., Michelsen, C. B., Elwyn, D. H., Furst, P., Kantrowitz, L., & Kinney, J. M. (1980). Muscle and plasma amino acids following injury: influence of intercurrent infection. Annals of Surgery, 192(1), 78.
Avellaneda, Y., Hernández, J., Ariza, C., & Afanador, T. (2008). Efecto de la suplementación de L-glutamina y L-glutamato (Aminogut®) sobre el crecimiento temprano de pollos de engorde. Revista de la Facultad de Medicina Veterinaria y de Zootecnia, 55(2), 77-90.
Ayazi, M. (2014). The effect of dietary glutamine supplementation on performance and blood parameter, carcass characteristics, quality and characteristics meat of broiler chickens under continuous heat stress condition. International Journal of Farming and Allied Sciences, 3(12), 1234-1242.
Bartell, S. M., & Batal, A. B. (2007). The effect of supplemental glutamine on growth performance, development of the gastrointestinal tract, and humoral immune response of broilers. Poultry Science, 86(9), 1940-1947. https://doi.org/10.1093/ps/86.9.1940
Bax, L., 2016. MIX 2.0 - Professional software for meta-analysis in Excel. Version 2.0.1.5. BiostatXL. Obtenido de: https://www.meta-analysis-made-easy.com/
Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2011). Introduction to meta-analysis. John Wiley & Sons.
Calder, P. C., & Yaqoob, P. (1999). Glutamine and the immune system. Amino acids, 17(3), 227-241. https://doi.org/10.1007/BF01366922
Dai, S. F., Gao, F., Zhang, W. H., Song, S. X., Xu, X. L., & Zhou, G. H. (2011). Effects of dietary glutamine and gamma-aminobutyric acid on performance, carcass characteristics and serum parameters in broilers under circular heat stress. Animal Feed Science and Technology, 168(1-2), 51-60. https://doi.org/10.1016/j.anifeedsci.2011.03.005
Dai, S. F., Wang, L. K., Wen, A. Y., Wang, L. X., & Jin, G. M. (2009). Dietary glutamine supplementation improves growth performance, meat quality and colour stability of broilers under heat stress. British Poultry Science, 50(3), 333-340. https://doi.org/10.1080/00071660902806947
Devi Priya, K., Selvaraj, P., Nanjappan, K., & Jayachandran, S. (2010). Oral supplementation of putrescine and l-glutamine on the growth performance, immunity, intestinal enzymes in the broiler chickens. Tamilnadu Journal of Veterinary and Animal Sciences, 6 (5), 250-254.
Fasina, Y. O., Bowers, J. B., Hess, J. B., & McKee, S. R. (2010). Effect of dietary glutamine supplementation on Salmonella colonization in the ceca of young broiler chicks. Poultry Science, 89(5), 1042-1048. https://doi.org/10.3382/ps.2009-00415
Higgins, J. P., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta‐analysis. Statistics in Medicine, 21(11), 1539-1558. https://doi.org/10.1002/sim.1186
Hu, H., Bai, X., Shah, A. A., Wen, A. Y., Hua, J. L., Che, C. Y., & Dai, S. F. (2016). Dietary supplementation with glutamine and γ‐aminobutyric acid improves growth performance and serum parameters in 22‐to 35‐day‐old broilers exposed to hot environment. Journal of Animal Physiology and Animal Nutrition, 100(2), 361-370. https://doi.org/10.1111/jpn.12346
Jazideh, F., Farhoomand, P., Daneshyar, M., & Najafi, G. (2014). The effects of dietary glutamine supplementation on growth performance and intestinal morphology of broiler chickens reared under hot conditions. Turkish Journal of Veterinary and Animal Sciences, 38(3), 264-270. https://doi.org/10.3906/vet-1210-32
Labow, B. I., Souba, W. W., & Abcouwer, S. F. (2001). Mechanisms governing the expression of the enzymes of glutamine metabolism–glutaminase and glutamine synthetase. The Journal of Nutrition, 131(9), 2467S-2474S. https://doi.org/10.1093/jn/131.9.2467S
Lean, I. J., Rabiee, A. R., Duffield, T. F., & Dohoo, I. R. (2009). Invited review: Use of meta-analysis in animal health and reproduction: Methods and applications. Journal of Dairy Science, 92(8), 3545-3565. https://doi.org/10.3168/jds.2009-2140
Luquetti, B. C., Alarcon, M. F., Lunedo, R., Campos, D. M., Furlan, R. L., & Macari, M. (2016). Effects of glutamine on performance and intestinal mucosa morphometry of broiler chickens vaccinated against coccidiosis. Scientia Agricola, 73(4), 322-327. http://dx.doi.org/10.1590/0103-9016-2015-0114
Maiorka, A., Silva, A. V., Santin, E., Dahlke, F., Bruno, L. D., Boleli, I. C., & Trautenmuller, H. (2016). Effect of broiler breeder age and glutamine supplementation on the development of the intestinal mucosa of 7-day-old chicks. Revista Brasileira de Ciência Avícola, 18(1), 17-22. http://dx.doi.org/10.1590/1516-635X1801017-022
Manvailer, G. V., Kiefer, C., de Souza, K. M., Marçal, D. A., Paiva, L. L., Rodrigues, G. P., & Ozelame, A. M. (2015). Glutamine for broilers reared in hot environment. Archivos de Zootecnia, 64(248), 377-382.
Menconi, A., Kallapura, G., Hernandez-Velasco, X., Latorre, J., Morgan, M., Pumford, N. R., & Barton, J. (2013). Effect of glutamine supplementation associated with probiotics on salmonella typhimurium and nitric oxide or glutamine with perinatal supplement on growth performance and intestinal morphology in broiler chickens. Clinical Microbiology, 2(120), 1-7. http://dx.doi.org/10.4172/2327-5073.1000120
Murakami, A. E., Sakamoto, M. I., Natali, M. R., Souza, L. M., & Franco, J. R. (2007). Supplementation of glutamine and vitamin E on the morphometry of the intestinal mucosa in broiler chickens. Poultry Science, 86(3), 488-495. https://doi.org/10.1093/ps/86.3.488
Muro, E. M., Pelícia, V. C., Vercese, F., de Souza, I. G., Pimenta, G. M., Oliveira, R. D., & Sartori, J. R. (2015). Aditivos fitogênicos e glutamina mais ácido glutâmico na dieta de frangos desafiados com coccidiose. Agrarian, 8(29), 304-311.
Mussini, F. J., Goodgame, S. D., Lu, C., Bradley, C. D., Fiscus, S. M., & Waldroup, P. W. (2012). A nutritional approach to the use of anticoccidial vaccines in broilers: glutamine utilization in critical stages of immunity acquisition. International Journal of Poultry Science, 11(4), 243-246.
Namroud, N. F., Shivazad, M., Zaghari, M., Madadgar, O., & Nourijelyani, K. (2017). Impact of dietary glutamine on amino acid digestibility values and intestinal morphometric parameters in neonate chicks. South African Journal of Animal Science, 47(4), 440-453. http://dx.doi.org/10.4314/sajas.v47i4.3
Nascimento, G. M., Leandro, N. S., Café, M. B., Stringhini, J. H., Andrade, M. A., Martinez, K. D., & Mascarenhas, A. G. (2014). Performance and intestinal characteristics of broiler chicken fed diet with glutamine in the diet without anticoccidials agents. Revista Brasileira de Saúde e Produção Animal, 15(3), 637-648. http://dx.doi.org/10.1590/S1519-99402014000300011
Nassiri Moghaddam, H., & Alizadeh-Ghamsari, A. H. (2013). Improved performance and small intestinal development of broiler chickens by dietary L-glutamine supplementation. Journal of Applied Animal Research, 41(1), 1-7. https://doi.org/10.1080/09712119.2012.738214
Newsholme, P. (2001). Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? The Journal of Nutrition, 131(9), 2515S-2522S. https://doi.org/10.1093/jn/131.9.2515S
Nitsan, Z., Dunnington, E. A. & Siegel, P. B., 1991. Organ growth and digestive enzyme levels to fifteen days of age in lines of chickens differing in body weight. Poultry Science, 70(10), 2040-2048. https://doi.org/10.3382/ps.0702040
Olubodun, J. O., Zulkifli, I., Farjam, A. S., Hair-Bejo, M., & Kasim, A. (2015). Glutamine and glutamic acid supplementation enhances performance of broiler chickens under the hot and humid tropical condition. Italian Journal of Animal Science, 14(1), 3263. https://doi.org/10.4081/ijas.2015.3263
Phanvijhitsiri, K., Musch, M. W., Ropeleski, M. J., & Chang, E. B. (2006). Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells. American Journal of Physiology-Cell Physiology, 291(2), C290-C299. https://doi.org/10.1152/ajpcell.00225.2005
Pohlenz, C., Buentello, A., Bakke, A. M., & Gatlin III, D. M. (2012). Free dietary glutamine improves intestinal morphology and increases enterocyte migration rates, but has limited effects on plasma amino acid profile and growth performance of channel catfish Ictalurus punctatus. Aquaculture, 370, 32-39. https://doi.org/10.1016/j.aquaculture.2012.10.002
Ribeiro, J. V., Albino, L. F., Rostagno, H. S., Hannas, M. I., Ribeiro, C. L., Vieira, R. A., & da Silva, D. L. (2015). Effects of dietary L-glutamine or L-glutamine plus L-glutamic acid supplementation programs on the performance and breast meat yield uniformity of 42-d-Old Broilers. Brazilian Journal of Poultry Science, 17(SPE), 93-98. http://dx.doi.org/10.1590/1516-635XSPECIALISSUENutrition-PoultryFeedingAdditives093-098
Roth, E. (2008). Nonnutritive effects of glutamine. The Journal of Nutrition, 138(10), 2025S-2031S. https://doi.org/10.1093/jn/138.10.2025S
Sakamoto, M. I., Faria, D. E., Nakagi, V. S., Negrão, J. A., Araújo, R. B., Souza, K. M., & Previero, T. C. (2011). Utilization of glutamine, associated with glutamic acid, on development and enzymatic activity in broiler chickens. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 63(4), 962-972. http://dx.doi.org/10.1590/S0102-09352011000400023
Salmanzadeh, M., Ebrahimnezhad, Y., Aghdam Shahryar, H., & Ghiasi Ghaleh-Kandi, J. (2016). The effects of in ovo feeding of glutamine in broiler breeder eggs on hatchability, development of the gastrointestinal tract, growth performance and carcass characteristics of broiler chickens. Archives Animal Breeding, 59(2), 235-242. https://doi.org/10.5194/aab-59-235-2016
Sauvant, D., Schmidely, P., Daudin, J. J., & St-Pierre, N. R. (2008). Meta-analyses of experimental data in animal nutrition. Animal, 2(8), 1203-1214. https://doi.org/10.1017/S1751731108002280
Shakeri, M., Oskoueian, E., Najafi, P., & Ebrahimi, M. (2015). Impact of glutamine in drinking water on performance and intestinal morphology of broiler chickens under high stocking density. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 42(1), 51-56. https://doi.org/10.16988/iuvfd.2016.42317
Sifa, D., Bai, X., Zhang, D., Hu, H., Wu, X., Wen, A., Zhao, L. (2018). Dietary glutamine improves meat quality, skeletal muscle antioxidant capacity and glutamine metabolism in broilers under acute heat stress. Journal of Applied Animal Research, 46(1), 1412-1417. https://doi.org/10.1080/09712119.2018.1520113
Soares, A. D., Costa, K. A., Wanner, S. P., Santos, R. G., Fernandes, S. O., Martins, F. S., & Cardoso, V. N. (2014). Dietary glutamine prevents the loss of intestinal barrier function and attenuates the increase in core body temperature induced by acute heat exposure. British Journal of Nutrition, 112(10), 1601-1610. https://doi.org/10.1017/S0007114514002608
Soltan, M. A. (2009). Influence of dietary glutamine supplementation on growth performance, small intestinal morphology, immune response and some blood parameters of broiler chickens. International Journal of Poultry Science, 8(1), 60-68.
Wang, H., Zhang, C., Wu, G., Sun, Y., Wang, B., He, B., ... & Wu, Z. (2014). Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of weanling piglets. The Journal of Nutrition, 145(1), 25-31. https://doi.org/10.3945/jn.114.202515
Wischmeyer, P. E. (2002). Glutamine and heat shock protein expression. Nutrition, 18(3), 225-228. https://doi.org/10.1016/S0899-9007(01)00796-1
Wu, G., Bazer, F. W., Johnson, G. A., Knabe, D. A., Burghardt, R. C., Spencer, T. E., & Wang, J. J. (2011). Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production. Journal of Animal Science, 89(7), 2017-2030. https://doi.org/10.2527/jas.2010-3614
Xue, G. D., Barekatain, R., Wu, S. B., Choct, M., & Swick, R. A. (2018). Dietary L-glutamine supplementation improves growth performance, gut morphology, and serum biochemical indices of broiler chickens during necrotic enteritis challenge. Poultry Science, 97(4), 1334-1341. https://doi.org/10.3382/ps/pex444
Yi, G. F., Allee, G. L., Knight, C. D., & Dibner, J. J. (2005). Impact of glutamine and oasis hatchling supplement on growth performance, small intestinal morphology, and immune response of broilers vaccinated and challenged with Eimeria maxima. Poultry Science, 84(2), 283-293. https://doi.org/10.1093/ps/84.2.283
Zavarize, K. C., Sartori, J., Pelícia, V., Pezzato, A., Araujo, P., Stradiotti, A., & Madeira, L. (2011). Glutamina e nucleotídeos na dieta de frangos de corte criados no sistema alternativo. Archivos de Zootecnia, 60(232), 913-920.
Zhong, X., Li, W., Huang, X., Wang, Y., Zhang, L., Zhou, Y., ... & Wang, T. (2012). Effects of glutamine supplementation on the immune status in weaning piglets with intrauterine growth retardation. Archives of Animal Nutrition, 66(5), 347-356. https://doi.org/10.1080/1745039X.2012.683325